This book aids in identifying when to apply adaptive randomization designs in practice. Featuring contributions from statisticians, clinical trialists, and subject-matter experts in academia and industry, the text discusses restricted, covariate-adaptive, response-adaptive, and covariate-adjusted response-adaptive randomization designs, as well as randomized designs with treatment selection. It describes a successful implementation of a single pivotal phase II/III adaptive trial in infants with proliferating hemangioma, addresses practical aspects of phase II dose-ranging studies, and examines…mehr
This book aids in identifying when to apply adaptive randomization designs in practice. Featuring contributions from statisticians, clinical trialists, and subject-matter experts in academia and industry, the text discusses restricted, covariate-adaptive, response-adaptive, and covariate-adjusted response-adaptive randomization designs, as well as randomized designs with treatment selection. It describes a successful implementation of a single pivotal phase II/III adaptive trial in infants with proliferating hemangioma, addresses practical aspects of phase II dose-ranging studies, and examines statistical monitoring and interim analysis issues in response-adaptive randomized clinical trials.
An Overview of Adaptive Randomization Designs in Clinical Trials. Efron's Biased Coin Design Revisited: Statistical Properties, Randomization-Based Inference, and Sequential Monitoring. Adaptive Biased Coins: Achieving Better Balance without Compromising Randomness. Brick Tunnel and Wide Brick Tunnel Randomization for Studies with Unequal Allocation. Development of Novel Covariate-Adaptive Randomization Designs. Optimal Model-Based Covariate-Adaptive Randomization Designs. Statistical Inference Following Covariate-Adaptive Randomisation: Recent Advances. Covariate-Adaptive Randomization with Unequal Allocation. Optimal Allocation Designs for a Multi-Arm Multi-Objective Clinical Trial. Response-Adaptive Randomization: An Overview of Designs and Asymptotic Theory. Statistical Inference Following Response-Adaptive Randomization. Sample Size Re-Estimation in Adaptively Randomized Clinical Trials with Missing Data. Some Caveats for Outcome Adaptive Randomization in Clinical Trials. Efficient and Ethical Adaptive Clinical Trial Designs to Detect Treatment-Covariate Interaction. Longitudinal Covariate-Adjusted Response-Adaptive Randomization: Impact of Missing Data. Targeted Covariate-Adjusted Response-Adaptive LASSO-Based Randomized Controlled Trials. Covariate-Balanced Bayesian Adaptive Randomization: Achieving Tradeoff Between Inferential and Ethical Goals in Small and Moderate Size Trials. Multi-Arm Multi-Stage Designs for Clinical Trials with Treatment Selection. Sequential Elimination in Multi-Arm Selection Trials. Accounting for Parameter Uncertainty in Two-Stage Designs for Phase II Dose-Response Studies. A Single Pivotal Adaptive Trial in Infants with Proliferating Hemangioma: Rationale, Design Challenges, Experience, and Recommendations. Practical Implementation of Dose-Response Adaptive Trials. Statistical Monitoring of Data in Response-Adaptive Randomized Clinical Trials.
An Overview of Adaptive Randomization Designs in Clinical Trials. Efron's Biased Coin Design Revisited: Statistical Properties, Randomization-Based Inference, and Sequential Monitoring. Adaptive Biased Coins: Achieving Better Balance without Compromising Randomness. Brick Tunnel and Wide Brick Tunnel Randomization for Studies with Unequal Allocation. Development of Novel Covariate-Adaptive Randomization Designs. Optimal Model-Based Covariate-Adaptive Randomization Designs. Statistical Inference Following Covariate-Adaptive Randomisation: Recent Advances. Covariate-Adaptive Randomization with Unequal Allocation. Optimal Allocation Designs for a Multi-Arm Multi-Objective Clinical Trial. Response-Adaptive Randomization: An Overview of Designs and Asymptotic Theory. Statistical Inference Following Response-Adaptive Randomization. Sample Size Re-Estimation in Adaptively Randomized Clinical Trials with Missing Data. Some Caveats for Outcome Adaptive Randomization in Clinical Trials. Efficient and Ethical Adaptive Clinical Trial Designs to Detect Treatment-Covariate Interaction. Longitudinal Covariate-Adjusted Response-Adaptive Randomization: Impact of Missing Data. Targeted Covariate-Adjusted Response-Adaptive LASSO-Based Randomized Controlled Trials. Covariate-Balanced Bayesian Adaptive Randomization: Achieving Tradeoff Between Inferential and Ethical Goals in Small and Moderate Size Trials. Multi-Arm Multi-Stage Designs for Clinical Trials with Treatment Selection. Sequential Elimination in Multi-Arm Selection Trials. Accounting for Parameter Uncertainty in Two-Stage Designs for Phase II Dose-Response Studies. A Single Pivotal Adaptive Trial in Infants with Proliferating Hemangioma: Rationale, Design Challenges, Experience, and Recommendations. Practical Implementation of Dose-Response Adaptive Trials. Statistical Monitoring of Data in Response-Adaptive Randomized Clinical Trials.
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