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This issue of Cardiology Clinics will cover Mitral Valve Disease. Curated by Dr. Takeshi Kitai, this issue will explore topics in the field that are relevant for practicing clinicians. This issue is one of four selected each year by the series editorial board: Jamil A. Aboulhosn, David M. Shavelle, Terrence D. Welch, and Audrey H. Wu. The volume will include articles on: Advances in mitral valve repair for degenerative mitral regurgitation: philosophy, technical details and long-term results, The role of surgical treatment of severe functional mitral regurgitation in heart failure, Role of mitral valve repair for mitral infective endocarditis, Optimal Timing of Surgery for Patients with Active Infective Endocarditis, Minimally invasive mitral surgery: Patient selection and technique, Current and future application of transcatheter mitral valve replacement, Echocardiographic evaluation of successful mitral valve repair or need for 2nd pump in the operating room, Multimodallity imaging for the assessment of mitral valve disease, Revisiting the role of guideline-directed medical therapy for patients with heart failure and severe functional mitral regurgitation and more.