Immo E. Scheffler

Mitochondria

• Gebundenes Buch

Produktbeschreibung

Praise for the First Edition:

"Very valuable."
-Journal of the American Aging Association

"Remarkably comprehensive yet concise and contains something for everyone . . . a wide range of 'Cell Biologists' will find this book valuable."
-Cell Biology International

"A broadly conceived and lively account of mitochondrial biology and biochemistry . . . [written] with such clarity and spark, and in such an organized and complete manner."
-Biochemistry and Molecular Biology Education

This book is the eagerly awaited Second Edition of the bestselling book widely acknowledged as the first modern, truly comprehensive work on mitochondria.

Mitochondria, Second Edition brings readers up to date on the many significant findings that have occurred since the book was first published nearly a decade ago. As in that seminal first edition, this Second Edition tackles the biochemistry, genetics, and pathology of mitochondria in different organisms. The growth of the subject has required more emphasis on mammalian mitochondria, but fundamental new insights from other organisms are also included. The new edition provides thorough updates of all the literature concerning this vital organelle, its functions, ongoing research surrounding it, and its importance vis-à-vis a broad range of issues in cellular and molecular biology. Mitochondria, Second Edition includes detailed descriptions of current and developing technologies involved in mitochondrial research and discovery, and highlights subjects that are growing, such as the use of proteomics.

Complete with black-and-white drawings and photographs, Mitochondria, Second Edition is an invaluable resource for all geneticists, biologists, and educators in the life sciences. It is also of interest to advanced students in genetics and molecular biology.

Produktdetails

• Verlag: Wiley & Sons
• Artikelnr. des Verlages: 14504073000
• 2. Aufl.
• Seitenzahl: 480
• Erscheinungstermin: 1. November 2007
• Englisch
• Abmessung: 236mm x 166mm x 29mm
• Gewicht: 820g
• ISBN-13: 9780470040737
• ISBN-10: 0470040734
• Artikelnr.: 22846035

Autorenporträt

Immo E. Scheffler, PhD, is Professor in the Division of Biology (Molecular Biology Section) at the University of California, San Diego. In addition to this well-received book, Dr. Scheffler has more than 100 original publications in scientific literature and has written numerous book chapters.

Inhaltsangabe

I. HISTORY. References. II. EVOLUTIONARY ORIGIN OF MITOCHONDRIA.
References. III. STRUCTURE AND MORPHOLOGY. INTEGRATION INTO THE CELL. 3.1
Structure and Morphology. 3.2 Integration into the Cell. 3.3. The dynamics
of mitochondrial morpholoy. References. IV. BIOGENESIS OF MITOCHONDRIA. 4.1
The Mitochondrial Genome. 4.2 Nuclear Genes encoding Mitochondrial
Proteins. Genome. 4.3 Replication and Maintenance of Mitochondrial DNA. 4.4
Transcription of Mitochondrial DNA - RNA Metabolism. 4.5 Translation of
mitochondrial mRNAs. 4.6 Protein Import into Mitochondria. 4.7 Import of
tRNA into Mitochondria. 4.8 Regulated Protein Degradation in Mitochondria.
References. V. MITOCHONDRIAL ELECTRON TRANSFER AND OXIDATIVE
PHOSPHORYLATION. 5.1 Historical Introduction. 5.2 The Electron Transport
Chain. 5.3 Electron Transport in Other Organisms. 5.4 The Chemiosmotic
Hypothesis. 5.5 ATP Synthase (F1Fo-ATPase). 5.6 Control of Respiration and
Oxidative Phosphorylation. 5.7. Reactive Oxygen Species. 5.8 Nitric Oxide
(NO). 5.9 The Role of Specific Lipids. References. VI. METABOLIC PATHWAYS
INSIDE MITOCHONDRIA. 6.1 Introduction. 6.2 The Krebs Cycle. 6.3 Fatty Acid
Metabolism. 6.4 The Urea Cycle. 6.5 Biosynthesis of Heme. 6.6 Cardiolipin
and Lipid Biosynthesis/Metabolism. 6.7 Biosynthesis of Ubiquinol (Coenzyme
Q). 6.8 Biosynthesis of Fe-S Centers. 6.9 Transport of small solutes into
and out of mitochondria. References. VII. MITOCHONDRIAL MUTATIONS AND
DISEASE. 7.1 General Introduction. 7.2 In Cell Culture. 7.3 Molecular
Genetics of Human Mitochondrial Diseases. 7.4 Mitochondrial DNA and Aging.
7.5 Mitochondria and Apoptosis. 7.6 Fungal Senescence. 7.7 Cytoplasmic Male
Sterility in Plants. References. VIII. MITOCHONDRIAL DNA SEQUENCING AND
ANTHROPOLOGY. 8.1 Introduction. 8.2 Human Evolution. 8.3 Primate Evolution.
8.4 Human Y chromosome variation. 8.5 Forensic Applications. 8.6 Future
Challenges. References. IX. MITOCHONDRIA AND PHARMACOLOGY. 9.1.
Introduction. References.

Rezensionen

"This volume inspires. It certainly will be much appreciated by cell biologists all over the world." ( Quarterly Review of Biology , March 2009) "Scheffler of California San Diego uses crisp, clear writing style and employs a broad perspective of current research and understanding of mitochondria." ( CHOICE , April 2008)