Methods and Applications of Statistics in Clinical Trials, Volume 2

Planning, Analysis, and Inferential Methods
Herausgegeben von Balakrishnan, N.

• Gebundenes Buch

Produktbeschreibung

This comprehensive book features both new and established material on the key statistical principles and concepts for designing modern-day clinical trials, such as hazard ratio, flexible designs, confounding, covariates, missing data, and longitudinal data. It discusses the various kinds of trials that can be found in today's clinical setting including open-labeled trials, multicentered trials, and superiority trials. It also explores such ongoing, cutting-edge trials as early cancer & heart disease, mother to child human immunodeficiency virus transmission, women's health initiative dietary, and AIDS.

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Methods and Applications of Statistics in Clinical Trials, Volume 2: Planning, Analysis, and Inferential Methods includes updates of established literature from the Wiley Encyclopedia of Clinical Trials as well as original material based on the latest developments in clinical trials. Prepared by a leading expert, the second volume includes numerous contributions from current prominent experts in the field of medical research. In addition, the volume features:

- Multiple new articles exploring emerging topics, such as evaluation methods with threshold, empirical likelihood methods, nonparametric ROC analysis, over- and under-dispersed models, and multi-armed bandit problems

- Up-to-date research on the Cox proportional hazard model, frailty models, trial reports, intrarater reliability, conditional power, and the kappa index

- Key qualitative issues including cost-effectiveness analysis, publication bias, and regulatory issues, which are crucial to the planning and data management of clinical trials

Produktdetails

• Methods and Applications of Statistics Vol.2
• Verlag: Wiley & Sons
• 1. Auflage
• Seitenzahl: 960
• Erscheinungstermin: 9. Juni 2014
• Englisch
• Abmessung: 261mm x 187mm x 55mm
• Gewicht: 1842g
• ISBN-13: 9781118304761
• ISBN-10: 1118304764
• Artikelnr.: 38479403

Autorenporträt

N. BALAKRISHNAN, PHD, is Professor in the Department of Mathematics and Statistics at McMaster University, Canada. He is the author of over twenty books and is the coeditor of Encyclopedia of Statistical Sciences, Second Edition, also published by Wiley.

Inhaltsangabe

Contributors xix Preface xxiii 1 Analysis of Over- and Underdispersed Data
1 2 Analysis of Variance (ANOVA) 10 3 Assessment of Health-Related Quality
of Life 26 4 Bandit Processes and Response-Adaptive Clinical Trials: The
Art of Exploration Versus Exploitation 40 5 Bayesian Dose-Finding Designs
in Healthy Volunteers 51 6 Bootstrap 62 7 Conditional Power in Clinical
Trial Monitoring 102 8 Cost-Effectiveness Analysis 111 9 Cox-Type
Proportional Hazards Models 126 10 Empirical Likelihood Methods in Clinical
Experiments 146 11 Frailty Models 166 12 Futility Analysis 174 13 Imaging
Science in Medicine I: Overview 187 14 Imaging Science in Medicine, II:
Basics of X-Ray Imaging 213 15 Imaging Science in Medicine, III: Digital
(21st Century) X-Ray Imaging 264 16 Intention-to-Treat Analysis 313 17
Interim Analyses 323 18 Interrater Reliability 334 19 Intrarater
Reliability 340 20 Kaplan-Meier Plot 357 21 Logistic Regression 365 22
Metadata 380 23 Microarray 392 24 Multi-Armed Bandits, Gittins Index, and
Its Calculation 416 25 Multiple Comparisons 436 26 Multiple Evaluators 446
27 Noncompartmental Analysis 457 28 Nonparametric ROC Analysis for
Diagnostic Trials 483 29 Optimal Biological Dose for Molecularly Targeted
Therapies 496 30 Over- and Underdispersion Models 506 31 Permutation Tests
in Clinical Trials 527 32 Pharmacoepidemiology, Overview 536 33 Population
Pharmacokinetic and Pharmacodynamic Methods 551 34 Proportions: Inferences
and Comparisons 570 35 Publication Bias 595 36 Quality of Life 608 37
Relative Risk Modeing 622 38 Sample Size Considerations for
Morbidity/Mortality Trials 633 39 Sample Size for Comparing Means 642 40
Sample Size for Comparing Proportions 653 41 Sample Size for Comparing
Time-to-Event Data 664 42 Sample Size for Comparing Variabilities 672 43
Screening, Models of 689 44 Screening Trials 721 45 Secondary Efficacy End
Points 731 46 Sensitivity, Specificity, and Receiver Operator
Characteristic (ROC) Methods 740 47 Software for Genetics/Genomics 752 48
Stability Study Designs 778 49 Subgroup Analysis 793 50 Survival Analysis,
Overview 802 51 The FDA and Regulatory Issues 815 52 The Kappa Index 836 53
Treatment Interruption 846 54 Trial Reports: Improving Reporting,
Minimizing Bias, and Producing Better Evidence-Based Practice 860 55 U.S.
Department of Veterans Affairs Cooperative Studies Program 876 56 Women's
Health Initiative: Statistical Aspects and Selected Early Results 901 57
World Health Organization (WHO): Global Health Situation 914 Index 925