Mechanotransduction

Volume 126
Herausgegeben:Engler, Adam J.; Kumar, Sanjay

• Gebundenes Buch

Produktbeschreibung

Progress in Molecular Biology and Translational Science provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology. It contains contributions from leaders in their fields and abundant references.

Volume 126 features in-depth reviews that focus on the tools required to investigate mechanotransduction. Additional chapters focus on how we can use these tools to answer fundamental questions about the interaction of physical forces with cell biology, morphogenesis, and function of mature structures. Chapters in the volume are authored by a unique combination of cell biologists and engineers, providing a range of perspectives on mechanotransduction.

Produktdetails

• Progress in Molecular Biology and Translational Science Volume 126
• Verlag: Academic Press / Elsevier Science & Technology
• Artikelnr. des Verlages: C2011-0-07845-6
• Seitenzahl: 384
• Erscheinungstermin: 23. Juli 2014
• Englisch
• Abmessung: 238mm x 159mm x 25mm
• Gewicht: 752g
• ISBN-13: 9780123946249
• ISBN-10: 0123946247
• Artikelnr.: 40919993

Inhaltsangabe

Subcellular tools for activating and measuring mechanotransductive signaling

1. The Detection and Role of Molecular Tension in Focal Adhesion DynamicsBrenton D. Hoffman2. Single Cell Imaging of Mechanotransduction in Endothelial CellsShaoying Lu and Yingxiao Wang

Focal adhesions as sensors

3. Focal Adhesions as SensorsJean-Cheng Kuo4. Focal Adhesions as SensorsWolfgang H. Goldmann5. Mechanical Cues Direct Focal Adhesion DynamicsKristina Haase, Zeinab Al-Rekabi and Andrew E. Pelling6. Molecular Mechanisms Underlying the Force-Dependent Regulation of Actin-to-ECM Linkage at the Focal AdhesionsHiroaki Hirata, Masahiro Sokabe and Chwee Teck Lim

Nuclear Mechanisms of Sensing

7. The Cellular Mastermind(?) - Mechanotransduction and the NucleusAshley Kaminski, Gregory R. Fedorchak and Jan Lammerding8. Nuclear Forces and Cell Mechano-SensingSamer Alam, David B. Lovett, Richard B. Dickinson, Kyle J. Roux and Tanmay P. Lele

Mechano-sensing in Stem Cells

9. From Stem Cells to Cardiomyocytes: The Role of Forces in Cardiac Maturation, Aging, and DiseaseGaurav Kaushik and Adam J. Engler10. Matrix Regulation of Tumor-Initiating CellsSophie Y. Wong and Sanjay Kumar11. Biomaterials Approaches in Stem Cell MechanobiologyNikolche Gjorevski and Matthias Lutolf

Multi-cellular Sensing

12. Mechanotransduction in C. elegans Morphogenesis and Tissue FunctionErin J. Cram13. Mechanical Force Sensing in TissuesSoline Chanet and Adam C. Martin

Rezensionen

Praise for the series:"Full of interest not only for the molecular biologist-for whom the numerous references will be invaluable-but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell." --British Medical Journal