Ligand Design in Medicinal Inorganic Chemistry - Storr, Tim
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Increasing the potency of therapeutic compounds, while limiting side-effects, is a common goal in medicinal chemistry. Ligands that effectively bind metal ions and also include specific features to enhance targeting, reporting, and overall efficacy are driving innovation in areas of disease diagnosis and therapy.
Ligand Design in Medicinal Inorganic Chemistry presents the state-of-the-art in ligand design for medicinal inorganic chemistry applications. Each individual chapter describes and explores the application of compounds that either target a disease site, or are activated by a…mehr

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Produktbeschreibung
Increasing the potency of therapeutic compounds, while limiting side-effects, is a common goal in medicinal chemistry. Ligands that effectively bind metal ions and also include specific features to enhance targeting, reporting, and overall efficacy are driving innovation in areas of disease diagnosis and therapy.

Ligand Design in Medicinal Inorganic Chemistry presents the state-of-the-art in ligand design for medicinal inorganic chemistry applications. Each individual chapter describes and explores the application of compounds that either target a disease site, or are activated by a disease-specific biological process.

Ligand design is discussed in the following areas:
Platinum, Ruthenium, and Gold-containing anticancer agents
Emissive metal-based optical probes
Metal-based antimalarial agents
Metal overload disorders
Modulation of metal-protein interactions in neurodegenerative diseases
Photoactivatable metal complexes and their use in biology and medicine
Radiodiagnostic agents and Magnetic Resonance Imaging (MRI) agents
Carbohydrate-containing ligands and Schiff-base ligands in Medicinal Inorganic Chemistry
Metalloprotein inhibitors

Ligand Design in Medicinal Inorganic Chemistry provides graduate students, industrial chemists and academic researchers with a launching pad for new research in medicinal chemistry.
Autorenporträt
Tim Storr, Department of Chemistry, Simon Fraser University, Canada Professor Storr has over thirteen years' experience in the field of bioinorganic chemistry and he currently has active research programs in cancer imaging using metal-based agents, and also in the design of metal binding agents for metal overload applications. He teaches a graduate course in bioinorganic chemistry at Simon Fraser University. Professor Storr was a member of the organizing committee for the 2011 International Conference on Biological Inorganic Chemistry, and is currently organizing a ligand design symposium at the upcoming 2012 Canadian Chemistry Conference.