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In recognition of the vital need to protect legitimate facilities from the theft and misuse of dangerous pathogens and toxins, this text is a guide to the implementation of pathogen protection programs. The first sections of the book offer an historical overview of biological weapons activity, key principles of biosecurity and its integration into existing frameworks, and a discussion of biosecurity risk. Later sections discuss risk assessments, describe detailed components of a biosecurity program, and offer a graded approach to biosecurity through multiple risk levels. The book also covers risk prioritization of biological assets and biosecurity training.