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Osteoarthritis (OA) is a type of degenerative articular disease that is slowly advancing and begins in the cartilage by breaking down and eventually spreads to the bones, soft tissues and synovial fluid. Clinically, osteoarthritis is diagnosed based on clinical examinations and a patient's medical history including joint pain such as aching or stiffness. This original textbook, based on medical research evidence, provides scientific knowledge to understand knee osteoarthritis.