Ketogenic therapies have treated epilepsy for 100 years. Now, broader clinical applications of metabolic therapies are coming to the fore and mechanistic understanding has increased dramatically. This 100th anniversary edition features top scientists and new insights, paralleled by increased appreciation for metabolic health among professionals and the public.
Ketogenic therapies have treated epilepsy for 100 years. Now, broader clinical applications of metabolic therapies are coming to the fore and mechanistic understanding has increased dramatically. This 100th anniversary edition features top scientists and new insights, paralleled by increased appreciation for metabolic health among professionals and the public.
Susan A. Masino Vernon D. Roosa Professor of Applied Science, Trinity College
Inhaltsangabe
* 1. General overview/introduction by co-editors, with a historical perspective * Section I. Ketogenic Diet for Epilepsy in the Clinic * 2. Overview: Ketogenic Diets and Pediatric Epilepsy: An Update * 3. 'Alternative' Ketogenic Diets * 4. Ketogenic Diet Therapies in Adults: History, Demand, and Results * 5. How Do You Implement the Diet? * 6. Glut1 Deficiency Syndrome and the Ketogenic Dietary Therapies * 7. Ketogenic Diet in Established Epilepsy Indications * 8. Ketogenic Diet for Other Epilepsies * 9. The Ketogenic Diets in Idiopathic Generalized Epilepsy Syndromes * 10. Ketogenic Diet Therapy for Infants with Pharmacoresistant Epilepsy and/or Metabolic Disease * 11. Ketogenic Diet in Status Epilepticus * 12. Preventing Side Effects and Diet Discontinuation * Section II. Ketogenic Diet: Emerging Clinical Applications and Future Potential * 13. Overview: Expanded Uses of Ketogenic Therapies * 14. Metabolism-Based Treatments for Managing Cancer: Scientific Rationale * 15. Ketogenic Diet as Adjunctive Therapy for Malignant Brain Cancer * 16. Ketogenic Diet, Social Behavior, and Autism: Insights from Animal Models * 17. Ketotherapeutics to Rescue Brain Energy Deficits: An Emerging Strategy to Delay Cognitive Decline in Alzheimer's Disease * 18. Ketogenic Diet and Ketones for Improving Neurological Outcomes after Acute Neurotrauma * 19. Ketogenic Diets and Neuroinflammation * 20. The Ketogenic Diet in the Treatment of Schizophrenia * 21. The Ketogenic Diet and the Gut Microbiome * Section III. Ketogenic Diet in the Laboratory * 22. Overview of Ketogenic Diet in the Laboratory: Progress on Models and Mechanisms * 23. Ketogenic Diet and PPARy * 24. Ketogenic Diet and Adenosine in Epilepsy - Models and Mechanisms * 25. Ketogenic Diet and Epigenetic Mechanisms of Epileptogenesis * 26. Ketogenic Diet, Aging, and Neurodegeneration * 27. Metabolic Seizure Resistance via BAD and KATP Channels * 28. Lactate Dehydrogenase: a Novel Metabolic Target * 29. Effects of the Ketogenic Diet on the Blood-Brain Barrier * 30. Metabolic and Redox Alterations by Ketogenic Diets * 31. Nicotinamide Adenine Dinucleotide as a Central Mediator of the Ketogenic therapy * Section IV. Ketone-Based Metabolism: General Health and Metabolic Alternatives * 32. Overview of Ketone-Based Metabolism: General Health and Metabolic Alternatives * 33. Ketone Supplementation for Health and Disease * 34. Neuroprotective and Behavioral Benefits of Exogenous Ketone Supplementation-evoked Ketosis * 35. Amino Acids in the Treatment of Neurological Disorders * 36. Identifying the Molecular Mechanism of the MCT (Ketogenic) Diet * 37. Triheptanoin in Epilepsy and Beyond * 38. Anti-seizure and Anti-epileptic Effects of Glycolysis Inhibition with 2-Deoxyglucose * 39. Low Carbohydrate, Ketogenic Diets for the Treatment of Type 2 Diabetes and Obesity * 40. Intermittent Exogenous Ketosis for Athletic Performance, Recovery and Adaptation * 41. Advancing the Awareness and Application of Metabolic and Ketogenic Therapies Globally and Offering Hope
* 1. General overview/introduction by co-editors, with a historical perspective * Section I. Ketogenic Diet for Epilepsy in the Clinic * 2. Overview: Ketogenic Diets and Pediatric Epilepsy: An Update * 3. 'Alternative' Ketogenic Diets * 4. Ketogenic Diet Therapies in Adults: History, Demand, and Results * 5. How Do You Implement the Diet? * 6. Glut1 Deficiency Syndrome and the Ketogenic Dietary Therapies * 7. Ketogenic Diet in Established Epilepsy Indications * 8. Ketogenic Diet for Other Epilepsies * 9. The Ketogenic Diets in Idiopathic Generalized Epilepsy Syndromes * 10. Ketogenic Diet Therapy for Infants with Pharmacoresistant Epilepsy and/or Metabolic Disease * 11. Ketogenic Diet in Status Epilepticus * 12. Preventing Side Effects and Diet Discontinuation * Section II. Ketogenic Diet: Emerging Clinical Applications and Future Potential * 13. Overview: Expanded Uses of Ketogenic Therapies * 14. Metabolism-Based Treatments for Managing Cancer: Scientific Rationale * 15. Ketogenic Diet as Adjunctive Therapy for Malignant Brain Cancer * 16. Ketogenic Diet, Social Behavior, and Autism: Insights from Animal Models * 17. Ketotherapeutics to Rescue Brain Energy Deficits: An Emerging Strategy to Delay Cognitive Decline in Alzheimer's Disease * 18. Ketogenic Diet and Ketones for Improving Neurological Outcomes after Acute Neurotrauma * 19. Ketogenic Diets and Neuroinflammation * 20. The Ketogenic Diet in the Treatment of Schizophrenia * 21. The Ketogenic Diet and the Gut Microbiome * Section III. Ketogenic Diet in the Laboratory * 22. Overview of Ketogenic Diet in the Laboratory: Progress on Models and Mechanisms * 23. Ketogenic Diet and PPARy * 24. Ketogenic Diet and Adenosine in Epilepsy - Models and Mechanisms * 25. Ketogenic Diet and Epigenetic Mechanisms of Epileptogenesis * 26. Ketogenic Diet, Aging, and Neurodegeneration * 27. Metabolic Seizure Resistance via BAD and KATP Channels * 28. Lactate Dehydrogenase: a Novel Metabolic Target * 29. Effects of the Ketogenic Diet on the Blood-Brain Barrier * 30. Metabolic and Redox Alterations by Ketogenic Diets * 31. Nicotinamide Adenine Dinucleotide as a Central Mediator of the Ketogenic therapy * Section IV. Ketone-Based Metabolism: General Health and Metabolic Alternatives * 32. Overview of Ketone-Based Metabolism: General Health and Metabolic Alternatives * 33. Ketone Supplementation for Health and Disease * 34. Neuroprotective and Behavioral Benefits of Exogenous Ketone Supplementation-evoked Ketosis * 35. Amino Acids in the Treatment of Neurological Disorders * 36. Identifying the Molecular Mechanism of the MCT (Ketogenic) Diet * 37. Triheptanoin in Epilepsy and Beyond * 38. Anti-seizure and Anti-epileptic Effects of Glycolysis Inhibition with 2-Deoxyglucose * 39. Low Carbohydrate, Ketogenic Diets for the Treatment of Type 2 Diabetes and Obesity * 40. Intermittent Exogenous Ketosis for Athletic Performance, Recovery and Adaptation * 41. Advancing the Awareness and Application of Metabolic and Ketogenic Therapies Globally and Offering Hope
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