Joint Modeling of Longitudinal CD4 Cell
Awol Seid
Broschiertes Buch

Joint Modeling of Longitudinal CD4 Cell

Count Measurements and Time-to- Default from Highly Active Antiretroviral Therapy (HAART): a Comparison of Separate and Joint Models

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Even if the beneficial effect of HAART, increasing survival and the prevention of AIDS defining illness are well established, many patients are defaulting from the treatment. Such defaulter patients are at high risk of illness and death. Therefore, defaulting is a critical issue that needs to be addressed so that maximum benefit from HAART can be obtained. In such follow-up and other clinical trials, both longitudinal and survival data are generated. Hence, joint models are used to describe the joint behaviour of a biomarker (longitudinal response) process and an associated survival process. T...