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Human cell-based medicinal products are heterogeneous with regard to the origin and type of the cells and to the complexity of the product.. Cells may be self-renewing stem cells, more committed progenitor cells or terminally differentiated cells exerting a specific defined physiological function. Cells may be of autologous or allogeneic origin. In addition, the cells may also be genetically modified. While cells may be used alone, associated with biomolecules or other chemical substances what is of relevance to this chapter are where cells are combined with structural materials that alone might be classified as medical devices.