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Migraine is a common disabling primary headache disorder as described by the International headache society. Primary headaches are disorders that exist without an apparent cause with recurrent and persistent head pain in comparison to secondary headaches which coexist with specific inciting factors There is a rise in the need for Complementary and Integrative medicine to provide long-term healing solutions in non-communicable diseases in general and Migraine headaches in particular. Knowing the limitations of the conventional medical approach, the present study, therefore, evaluated the influence of the two Indian traditional systems of medicine, i.e., Ayurveda and Yoga as an integrative medical intervention. Changes following the use of Ayurveda and Yoga therapy were studied on symptoms, migraine-related disability, perceived stress, autonomic variables, muscle activity, and quality of life in patients with migraine headache without aura.