Insulin Resistance
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In the mid 1990s, Drs. Gerald Reaven identified a constellation of clinical findings, known variously as the metabolic syndrome, syndrome X, insulin resistance s- drome or insulin resistance-related disorders, that are associated with an increased risk of heart disease and diabetes. Interest in this topic grew rapidly, culminating in the publication by this series of the book, Insulin Resistance and the Metabolic Syndrome X, edited by Drs. Reaven and Laws in 1999. Since the original publication of that now classic volume, the world's population has continued to become more obese and sedentary…mehr

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In the mid 1990s, Drs. Gerald Reaven identified a constellation of clinical findings, known variously as the metabolic syndrome, syndrome X, insulin resistance s- drome or insulin resistance-related disorders, that are associated with an increased risk of heart disease and diabetes. Interest in this topic grew rapidly, culminating in the publication by this series of the book, Insulin Resistance and the Metabolic Syndrome X, edited by Drs. Reaven and Laws in 1999. Since the original publication of that now classic volume, the world's population has continued to become more obese and sedentary and the prevalence of disorders related to insulin resistance has continued to increase throughout the developed and developing world. Of great concern in the last decade is the extension of these deleterious lifestyle patterns to the pediatric population, leading to both obesity and the appearance of insulin resistance-related disorders in youth as well as adults. Today, about one in three children and adolescents in the United States is overweight or obese, and this prevalence approaches one in two among adolescents in certain minority groups. In addition, components of this cardiovascular risk constellation are now being recognized in young adults, adolescents, and even children. Youth are increasingly developing type 2 diabetes, fatty liver disease, hypertriglyceridemia, hypertension, polycystic ovarian syndrome, sleep apnea, orthopedic and psychiatric complications, as well as other complications of obesity and insulin resistance.
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From the reviews:

"The editors have gathered world experts in this recently recognized problem in children as well as in the adult disease. Molecular mechanisms and disturbances in physiologic functioning are well covered and need appreciation by comprehensive therapists. Contributors to this book make this learning seem to be easy." (William H Wehrmacher, Comprehensive Therapy, December, 2008)

"Editors Philip Zeitler and Kristen Nadeau have assembled a comprehensive and insightful textbook on the timely topic of insulin resistance and the pediatric antecedents of insulin resistance that lead to adult diseases such as diabetes and cardiovascular disease. ... Many chapters include excellent tables and figures. ... overall, the book is worth the investment in time and money for those with either research or clinical interests in this area." (Lori Laffel, The New England Journal of Medicine, Vol. 360 (20), May, 2009)

"This volume is part of the Series Contemporary Endocrinology. ... The book has 3 parts. ... Clearly written, it is recommended to pediatric endocrinologists and nutritionists." (Pediatric Endocrinology Reviews, Vol. 7 (4), June, 2010)

"Insulin Resistance: Childhood Precursors and Adult Disease, edited by Philip S. Zeitler and Kristen J. Nadeau, provides a timely and comprehensive overview of insulin resistance in children, and the clustering of associated metabolic and cardiovascular risk factors known as the metabolic syndrome. ... this book would be a useful resource for any primary care physician or pediatric subspecialist. ... a helpful resource for any physician seeking to expand his or her understanding of current concepts of insulin resistance and related co-morbid conditions in childhood." (Stavra A. Xanthakos, Practical Gastroenterology, April, 2009)

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