Ana Filipa Ferreira, Aileen Rowan, Charles Bangham

Immune response to virus

Quantification of T cell responses to HTLV-1: balance of inflammatory and antiviral effects

• Broschiertes Buch

Produktbeschreibung

Despite abundant activated Human T cell Lymphotropic Virus type 1 (HTLV-1)-specific Cytotoxic T Lymphocytes (CTL), patients with HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) show a significantly higher frequency of infected cells than Asymptomatic Carriers (AC) of the virus. In order to further characterise the CTL response to HTLV-1, an assay to quantify specific T cell effector functions was developed. I analysed degranulation (by CD107 mobilisation) and cytokine (IFN- and TNF- ) expression by both HTLV-1-specific CD8+ and CD4+ T cells in response to HTLV-1 Tax peptide. This study shows a trend of the frequency of degranulating CD8+ T cells to be higher in HAM/TSP patients, however at a given proviral load the rate of lysis of infected cells tend to be higher in ACs than in HAM/TSP patients. Interestingly, only the frequency of CTL degranulation correlated with the rate of killing of target cells, suggesting that CTL killing of target cells depends mainlyon degranulation.

Produktdetails

• Verlag: LAP Lambert Academic Publishing
• Aufl.
• Seitenzahl: 80
• Erscheinungstermin: 3. Januar 2012
• Englisch
• Abmessung: 220mm x 150mm x 5mm
• Gewicht: 137g
• ISBN-13: 9783846542798
• ISBN-10: 3846542792
• Artikelnr.: 34737716

Autorenporträt

Filipa was born in Lisbon, Portugal in 1986. She graduated in Cell & Molecular Biology (2007) and earned a master¿s degree in Molecular Genetics & Biomedicine (2009) from Univ. Nova Lisboa. The present MSc thesis was developed in Imperial College London. Now, Filipa is a PhD student from the GABBA Program doing her research in both Lisbon and USA.