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The right to quality health care is one of the internationally recognized fundamental human rights for all people regardless of religion, culture or social class. Lack of quality health care in Nigeria has led to poor quality of life for the citizens. Few empirical studies exist to ascertain the level of quality health service delivery in Nigeria, even though the general public perceived this important service as low. This study provided empirical evidence on the quality of health service delivery in Federal tertiary hospitals in Nigeria and the extent to which quality health service delivery is predicted by information technology application. The study employed survey research design. The population for the study was 479 health professionals comprising 204 Medical Doctors, 180 Nurses and 95 Health Information Management Officers from the Federal tertiary hospitals in the country. Instrument for data collection was structure questionnaire. The reliability test of the variables ranged from = 0.84 - 0.93. A response rate of 87% was obtained. Data were analyzed using frequencies and multiple regression analysis.