The International Brain Hypothermia Symposium 2004was the second time I have had the honor of opening such a gathering on brain hypothermia treatment. It was a great pleasure to greet the participants in the hope that their valuablecontributions would make the Tokyo meeting memorable. Brainhypothermia has long been seen as a promising method that may overcome current limitations on brain resuscitation in patients with severe brain damage. However, although excellentresults have been obtained in experimental animal models, for some reason brain hypothermia has not alwaysbeen successful…mehr
The International Brain Hypothermia Symposium 2004was the second time I have had the honor of opening such a gathering on brain hypothermia treatment. It was a great pleasure to greet the participants in the hope that their valuablecontributions would make the Tokyo meeting memorable. Brainhypothermia has long been seen as a promising method that may overcome current limitations on brain resuscitation in patients with severe brain damage. However, although excellentresults have been obtained in experimental animal models, for some reason brain hypothermia has not alwaysbeen successful clinically,and resolving this problem has been a major challenge facing physicians specializing in brain therapies. The ICUmanagement of recent research has uncovered newmechanisms ofbrain damage not seen in animal models, including brain thermo-pooling at temperatures above 40°C in severe brain damage, masking neuronal hypoxia even with normal cerebral blood flow. Stress-related hyper glycemia withbrain hypothermia was expected to generate useful results in patients with external injuries, cerebral occlusive stroke, and cardiac arrest. In recent clinical studies of brain hypothermia treatment, many excellent results began being reported on the manage ment of severe brain injury, ischemic stroke, and post-resuscitation after cardiac arrest. However, in clinical brain hypothermia treatment many questions remained about appro priate treatment targets, leu management technique, prevention of complications, control of brain tissue temperature,management of hypothermia insult,and mechanisms underly ing the onset of vegetative states.
Nariyuki HayashiProfessor and Chairman, Department of Emergency and Critical Care Medicine, Nihon University School of Medicine Ross BullockDepartment of Neurosurgery, Virginia Commonwealth University Health System, USA Dalton W. DietrichDepartment of Neurological Surgery, The Miami Project to Cure Paralysis, University of Miami School of Medicine, USA Tsuyoshi MaekawaDepartment of Emergency and Critical Care Medicine, Yamaguchi University Hospital, Japan Akira TamuraTeikyo University School of Medicine, Japan
Inhaltsangabe
1. Opening the Door to Hypothermia Historical Review of the Development of Brain Hypothermia 2. Up-to-date Basic Science of Hypothermia A Review of the Protective Effects of Hypothermia on the Axonal and Vascular Pathobiology Associated with Traumatic Brain Injury Factors Regulating Hypothermic Protection in Experimental Models of Brain Injury Effects of Brain Hypothermia on Brain Edema Formation After Intracerebral Hemorrhage in Rats Hypothermia Prolongs Survival Time of Severely Septic Rats: A Study Using a Computer-Supported Multichannel Thermoregulatory System Influence of Hypothermia on Neuroprotective Effect of Inhibiting Neurotransmitters and Agonists of Their Receptors 3. Development of Brain Hypothermia Treatment A New Concept of Brain Hypothermia Treatment and Pitfalls in Intensive Care Unit Hypothermia Management 4. Technique and ICU Management of Brain Hypothermia Is Hypothermia Beneficial by Preventing Fever? Management of Induced Hypothermia in the Intensive Care Unit Microdialysis for Time Course of Extracellular Glutamate in Poor-Grade Aneurysm Patients: Preliminary Study Mild Brain Hypothermia Suppresses Oxygen Free Radicals in Patients with Neuroemergency: An Ex Vivo Electron Spin Resonance Study Mathematical Analysis of Extremity Immersion Cooling for Brain Temperature Management Rapid Induction of Brain Hypothermia by Selective Intra-Arterial Perfusion of Crystalloid Solution in an Animal Model Combination of Forced Air Cooling, Cooling by Circulating Water Mattress, and Intravenous Bolus Infusion of Iced Saline Is an Effective and Safe Technique for Induction of Mild Hypothermia During Cerebral Aneurysm Surgery Automatic Air-Cooling Incubating System for Brain Hypothermia Treatment Automatic Temperature Management System in Patients with Mild Hypothermia: Three Case Reports Intraoperative Mild Hypothermia in Neurosurgery The Importance of Nursing Management in the Treatment of Brain Hypothermia 5. Hypothermia Response Moderate Hypothermia Attenuates the Endothelium-Dependent Pial Arteriole Dilatation but Not the Endothelium-Independent Response in Rats Pial Microcirculation Evaluated by Closed Cranial Window Method 7 Days After Impact Acceleration Injury in Rats: Does Post-Traumatic Hypothermia Provide Persisting Pial Vascular Protection? 6. Neonate and Pediatric Brain Hypothermia Hypothermia Following Traumatic Brain Injury in Children Clinical Study of Brain Magnetic Resonance Images in Infants with Brain Hypothermia Study on Body Temperature Monitoring During Brain Hypothermia in Newborn Infants with Severe Hypoxic-Ischemic Encephalopathy Neuropsychological Recovery in Pediatric Patients with Acute Subdural Hematoma Treated with Mild Hypothermia Therapy: Report of Two Cases Adjunctive Therapy Application of Hyperbaric Oxygen Therapy in Children Already Treated with Mild Hypothermia for Disturbance of Consciousness 7. Experimental Research and Clinical Management The Management of Cerebral Stroke by Brain Hypothermia Treatment The Nordic Cooling Stroke Study-NOCSS. A Multicenter Study of Induced Mild Hypothermia in Acute Stroke Patients. Ongoing Clinical Trial Hypothermia in the Therapy of Ischemic Stroke Correlation of Hypothermia with Decrease of Glutathione Concentration and Tolerance to Cerebral Ischemia Hypothermia Prolongs the Viability of Ischemic Brain Tissue Due to Neuroprotection Linked to Redistribution of Oxygen in Brain: Positron Emission Tomography Study of the Critical First 6h After Stroke in Pigs Neuroprotective Effects of Selective Brain Hypothermia (SBH) on Permanent Focal Cerebral Ischemia in Rats The Effects of Mild and Deep Hypothermia on the Neuronal Activity and Energy
1. Opening the Door to Hypothermia Historical Review of the Development of Brain Hypothermia 2. Up-to-date Basic Science of Hypothermia A Review of the Protective Effects of Hypothermia on the Axonal and Vascular Pathobiology Associated with Traumatic Brain Injury Factors Regulating Hypothermic Protection in Experimental Models of Brain Injury Effects of Brain Hypothermia on Brain Edema Formation After Intracerebral Hemorrhage in Rats Hypothermia Prolongs Survival Time of Severely Septic Rats: A Study Using a Computer-Supported Multichannel Thermoregulatory System Influence of Hypothermia on Neuroprotective Effect of Inhibiting Neurotransmitters and Agonists of Their Receptors 3. Development of Brain Hypothermia Treatment A New Concept of Brain Hypothermia Treatment and Pitfalls in Intensive Care Unit Hypothermia Management 4. Technique and ICU Management of Brain Hypothermia Is Hypothermia Beneficial by Preventing Fever? Management of Induced Hypothermia in the Intensive Care Unit Microdialysis for Time Course of Extracellular Glutamate in Poor-Grade Aneurysm Patients: Preliminary Study Mild Brain Hypothermia Suppresses Oxygen Free Radicals in Patients with Neuroemergency: An Ex Vivo Electron Spin Resonance Study Mathematical Analysis of Extremity Immersion Cooling for Brain Temperature Management Rapid Induction of Brain Hypothermia by Selective Intra-Arterial Perfusion of Crystalloid Solution in an Animal Model Combination of Forced Air Cooling, Cooling by Circulating Water Mattress, and Intravenous Bolus Infusion of Iced Saline Is an Effective and Safe Technique for Induction of Mild Hypothermia During Cerebral Aneurysm Surgery Automatic Air-Cooling Incubating System for Brain Hypothermia Treatment Automatic Temperature Management System in Patients with Mild Hypothermia: Three Case Reports Intraoperative Mild Hypothermia in Neurosurgery The Importance of Nursing Management in the Treatment of Brain Hypothermia 5. Hypothermia Response Moderate Hypothermia Attenuates the Endothelium-Dependent Pial Arteriole Dilatation but Not the Endothelium-Independent Response in Rats Pial Microcirculation Evaluated by Closed Cranial Window Method 7 Days After Impact Acceleration Injury in Rats: Does Post-Traumatic Hypothermia Provide Persisting Pial Vascular Protection? 6. Neonate and Pediatric Brain Hypothermia Hypothermia Following Traumatic Brain Injury in Children Clinical Study of Brain Magnetic Resonance Images in Infants with Brain Hypothermia Study on Body Temperature Monitoring During Brain Hypothermia in Newborn Infants with Severe Hypoxic-Ischemic Encephalopathy Neuropsychological Recovery in Pediatric Patients with Acute Subdural Hematoma Treated with Mild Hypothermia Therapy: Report of Two Cases Adjunctive Therapy Application of Hyperbaric Oxygen Therapy in Children Already Treated with Mild Hypothermia for Disturbance of Consciousness 7. Experimental Research and Clinical Management The Management of Cerebral Stroke by Brain Hypothermia Treatment The Nordic Cooling Stroke Study-NOCSS. A Multicenter Study of Induced Mild Hypothermia in Acute Stroke Patients. Ongoing Clinical Trial Hypothermia in the Therapy of Ischemic Stroke Correlation of Hypothermia with Decrease of Glutathione Concentration and Tolerance to Cerebral Ischemia Hypothermia Prolongs the Viability of Ischemic Brain Tissue Due to Neuroprotection Linked to Redistribution of Oxygen in Brain: Positron Emission Tomography Study of the Critical First 6h After Stroke in Pigs Neuroprotective Effects of Selective Brain Hypothermia (SBH) on Permanent Focal Cerebral Ischemia in Rats The Effects of Mild and Deep Hypothermia on the Neuronal Activity and Energy
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