The eleventh monograph and meeting of the Foundation on "Hormon al Control of the Hypothalamo-Pituitary-Gonadal Axis" was held in October 1983 at the Weizmann Institute of Science. This monograph honors the memory of Professor Hans R. Lindner, a productive and innovative scientist greatly respected and admired by his col leagues. When addressing the opening session I remarked that my impres sion of the Weizmann Institute was one or two large buildings hous ing the various departments. This was my first visit to Israel and I was overwhelmed by the beautiful semi-tropical gardens of the in…mehr
The eleventh monograph and meeting of the Foundation on "Hormon al Control of the Hypothalamo-Pituitary-Gonadal Axis" was held in October 1983 at the Weizmann Institute of Science. This monograph honors the memory of Professor Hans R. Lindner, a productive and innovative scientist greatly respected and admired by his col leagues. When addressing the opening session I remarked that my impres sion of the Weizmann Institute was one or two large buildings hous ing the various departments. This was my first visit to Israel and I was overwhelmed by the beautiful semi-tropical gardens of the in stitute, in a setting of shrubs and trees, orange groves and flow ers. Sited among this seventy-five acres are over fifty buildings and residential areas for the staff and visiting scientists. I saw pictures of this area when Dr. Chaim Weizmann founded in 1934, the Daniel Sieff Research Institute, the forerunner of the Weizmann In stitute. The site was sand dunes without a blade of grass. That the desert shall bloom is illustrative of the progress made in Is rael. The topics of the monograph are grouped into twelve sections.
Neuroendocrine Control of Gonadotropin Secretion.- Role of Peptides in the Control of Gonadotropin Secretion.- Molecular Aspects of the Release of Luteinizing Hormone Releasing Hormone (LHRH) from Hypothalamic Neurons.- Role of Peptides in the Regulation of Gonadotropin and Prolactin Secretion.- Estrous Cycle Dependent Modulation of Muscarinic Cholinergic Receptors in the Hypothalamus and Adenohypophysis.- Molecular Aspects of GnRH Biosynthesis, Release, and Degreadation.- Hormones and Other Messenger Molecules: An Approach to Unity.- Regulation of the Synthesis, Release and Action of Hypothalamic Luteinizing Hormone Releasing Hormone.- Degradation of LH-RH.- Degradation of Luteinizing Hormone-Releasing Hormone by Rat Pituitary Plasma Membrane Associated Enzymes.- GnRH Receptors and Action in the Pituitary.- GnRH Receptors: Identification, Localization, and Implications for Biological Function.- Physiological Regulation of Pituitary GnRH Receptors.- GnRH Recpetor Microaggregation: Regulation of Gonadotropin Release, GnRH Receptors, and Gonadotrope Responsiveness.- Secretory Processes in the Pituitary.- Recent Progress in Cell Biology of Secretory Process in Anterior Pituitary Cells.- Fluidity of Gonadotropin Storage in Cycling Female Rats.- Regulation of Peptide Hormone Receptors in the Pituitary-Gonadal Axis: Receptors to Gonadotropins and Gonadotropin Releasing Hormone.- Gonadotropin Antagonists.- Strategies for the Inhibition of Gonadotropin Action.- The Role of Carbohydrate Moiety of Gonadotropin Molecule in Transduction of Biological Signal.- Endocrine Regulation of Ovarian Functions.- Intraovarian Regulation of Follicular Granulosa Cell Differentiation.- Calcium: A Cellular Mediator of Luteolysis.- New Perspectives on the Endocrine Regulation of the Rabbit CorpusLuteum.- Secretion and Action of Steroids in the Luteal Cell.- Hormones in Antral Fluid and the Regulation of Ovarian Function.- Regulation of Oocyte Maturation.- Mechanisms involved in the Follicular Rupture in the Rat.- Prolactin.- The Role of Cell-Cell Communication in Neuropeptide-Stimulated and Dopamine-Inhibited Prolactin Release.- Modulation of Prolactin Secretion at the Pituitary Level: Involvement of Adenylate Cyclase.- Hormones and Gene Expression.- Hormonal Regulation of Casein in Gene Expression in Normal and Transformed Mammary Cells.- In Vivo Regulation by Estradiol of the Messenger RNAs Encoding LH and FSH Subunits and the Secretion of Gonadotropins.- Regulation of Testicular Function.- Follicle Stimulating Hormone Regulation of Phosphodiesterase and Cell Response.- Regulation of Steroidogenic Activities in Leydig Cells by LH and an LHRH Agonist.- Extrapituitary Effects of GnRH.- Molecular Heterogeneity of Luteinizing Hormone-Releasing Hormone.- The Biological Actions of 'Testicular LHRH'.- Luteinizing Hormone-Releasing Hormone Independently Stimulates Cytodifferentiation of Granulosa Cells.- Action of LHRH Analogues on Rat Leydig Cells In Vitro: Effects on Cyclic AMP, Ca2+, Cholesterol Side Chain Cleavage and Cell Size.- Phospholipid Turnover in Gonadotropin-Releasing Hormone Target Cells: Comparative Studies.- Interaction of Opiates and Gonadotropins.- Relation of Endogenous Opiates to Secretion of Gonadotropins.- GnRH analogs: Clinical Uses in the Management of Fertility and Cancer.- Structure-Function of LH-RH Analogs and Design Applications to Other Peptide Systems.- Medical Castration with LHRH Agonists and the Need for Combined Treatment with an Antiandrogen in Prostate Cancer.- Potential Uses of LHRH and Analogues: Clinical Implications.-Application of GnRH for Induction of Ovulation in Anovulatory Menstruating Women.- Pulsatile Administration of GnRH in Hypothalamic Amenorrhea.- On the Mode of Action of an LHRH Agonist in Man and Its Potential Use as Contraceptive.- Hypothalamic-Pituitary-Gonadal Axis: Concluding Remarks.
Neuroendocrine Control of Gonadotropin Secretion.- Role of Peptides in the Control of Gonadotropin Secretion.- Molecular Aspects of the Release of Luteinizing Hormone Releasing Hormone (LHRH) from Hypothalamic Neurons.- Role of Peptides in the Regulation of Gonadotropin and Prolactin Secretion.- Estrous Cycle Dependent Modulation of Muscarinic Cholinergic Receptors in the Hypothalamus and Adenohypophysis.- Molecular Aspects of GnRH Biosynthesis, Release, and Degreadation.- Hormones and Other Messenger Molecules: An Approach to Unity.- Regulation of the Synthesis, Release and Action of Hypothalamic Luteinizing Hormone Releasing Hormone.- Degradation of LH-RH.- Degradation of Luteinizing Hormone-Releasing Hormone by Rat Pituitary Plasma Membrane Associated Enzymes.- GnRH Receptors and Action in the Pituitary.- GnRH Receptors: Identification, Localization, and Implications for Biological Function.- Physiological Regulation of Pituitary GnRH Receptors.- GnRH Recpetor Microaggregation: Regulation of Gonadotropin Release, GnRH Receptors, and Gonadotrope Responsiveness.- Secretory Processes in the Pituitary.- Recent Progress in Cell Biology of Secretory Process in Anterior Pituitary Cells.- Fluidity of Gonadotropin Storage in Cycling Female Rats.- Regulation of Peptide Hormone Receptors in the Pituitary-Gonadal Axis: Receptors to Gonadotropins and Gonadotropin Releasing Hormone.- Gonadotropin Antagonists.- Strategies for the Inhibition of Gonadotropin Action.- The Role of Carbohydrate Moiety of Gonadotropin Molecule in Transduction of Biological Signal.- Endocrine Regulation of Ovarian Functions.- Intraovarian Regulation of Follicular Granulosa Cell Differentiation.- Calcium: A Cellular Mediator of Luteolysis.- New Perspectives on the Endocrine Regulation of the Rabbit CorpusLuteum.- Secretion and Action of Steroids in the Luteal Cell.- Hormones in Antral Fluid and the Regulation of Ovarian Function.- Regulation of Oocyte Maturation.- Mechanisms involved in the Follicular Rupture in the Rat.- Prolactin.- The Role of Cell-Cell Communication in Neuropeptide-Stimulated and Dopamine-Inhibited Prolactin Release.- Modulation of Prolactin Secretion at the Pituitary Level: Involvement of Adenylate Cyclase.- Hormones and Gene Expression.- Hormonal Regulation of Casein in Gene Expression in Normal and Transformed Mammary Cells.- In Vivo Regulation by Estradiol of the Messenger RNAs Encoding LH and FSH Subunits and the Secretion of Gonadotropins.- Regulation of Testicular Function.- Follicle Stimulating Hormone Regulation of Phosphodiesterase and Cell Response.- Regulation of Steroidogenic Activities in Leydig Cells by LH and an LHRH Agonist.- Extrapituitary Effects of GnRH.- Molecular Heterogeneity of Luteinizing Hormone-Releasing Hormone.- The Biological Actions of 'Testicular LHRH'.- Luteinizing Hormone-Releasing Hormone Independently Stimulates Cytodifferentiation of Granulosa Cells.- Action of LHRH Analogues on Rat Leydig Cells In Vitro: Effects on Cyclic AMP, Ca2+, Cholesterol Side Chain Cleavage and Cell Size.- Phospholipid Turnover in Gonadotropin-Releasing Hormone Target Cells: Comparative Studies.- Interaction of Opiates and Gonadotropins.- Relation of Endogenous Opiates to Secretion of Gonadotropins.- GnRH analogs: Clinical Uses in the Management of Fertility and Cancer.- Structure-Function of LH-RH Analogs and Design Applications to Other Peptide Systems.- Medical Castration with LHRH Agonists and the Need for Combined Treatment with an Antiandrogen in Prostate Cancer.- Potential Uses of LHRH and Analogues: Clinical Implications.-Application of GnRH for Induction of Ovulation in Anovulatory Menstruating Women.- Pulsatile Administration of GnRH in Hypothalamic Amenorrhea.- On the Mode of Action of an LHRH Agonist in Man and Its Potential Use as Contraceptive.- Hypothalamic-Pituitary-Gonadal Axis: Concluding Remarks.
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