John A. Joule, Keith Mills

Heterocyclic Chemistry

• Broschiertes Buch

Produktbeschreibung

This book has so closely matched the requirements of itsreadership over the years that it has become the first choice forchemists worldwide.
Heterocyclic chemistry comprises at least half of all organicchemistry research worldwide. In particular, the vast majority oforganic work done in the pharmaceutical and agrochemical industriesis heterocyclic chemistry.

The fifth edition of Heterocyclic Chemistry maintains theprincipal objective of earlier editions - to teach thefundamentals of heterocyclic reactivity and synthesis in a way thatis understandable to second- and third-year undergraduate chemistrystudents. The inclusion of more advanced and current material alsomakes the book a valuable reference text for postgraduate taughtcourses, postgraduate researchers, and chemists at all levelsworking with heterocyclic compounds in industry.

Fully updated and expanded to reflect important 21 st century advances, the fifth edition of this classic text includesthe following innovations:

Extensive use of colour to highlight changes in structure andbonding during reactions
Entirely new chapters on organometallic heterocyclic chemistry,heterocyclic natural products, especially in biochemical processes,and heterocycles in medicine
New sections focusing on heterocyclic fluorine compounds,isotopically labeled heterocycles, and solid-phase chemistry,microwave heating and flow reactors in the heterocycliccontext
Essential teaching material in the early chapters is followed byshort chapters throughout the text which capture the essence ofheterocyclic reactivity in concise resumés suitable asintroductions or summaries, for example for examinationpreparation. Detailed, systematic discussions cover the reactivityand synthesis of all the important heterocyclic systems. Originalreferences and references to reviews are given throughout the text,vital for postgraduate teaching and for research scientists.Problems, divided into straightforward revision exercises, and morechallenging questions (with solutions available online), help thereader to understand and apply the principles of heterocyclicreactivity and synthesis.

Produktdetails

• Verlag: Blackwell Publishers
• 5th ed.
• Seitenzahl: 720
• Erscheinungstermin: 13. April 2010
• Englisch
• Abmessung: 245mm x 195mm x 40mm
• Gewicht: 1685g
• ISBN-13: 9781405133005
• ISBN-10: 1405133007
• Artikelnr.: 20898402

Autorenporträt

John Joule is Emeritus Professor in the School of Chemistry, The University of Manchester, UK Keith Mills spent 25 years in the Medicinal Chemistry and Development Chemistry departments at GlaxoSmithKline, Stevenage, UK, and is now an independent consultant.

Inhaltsangabe

Preface Definitions of abbreviations 1. Heterocyclic nomenclature 2.
Structures and spectroscopic properties of aromatic heterocycles 3.
Substitutions of aromatic heterocycles 4. Organometallic heterocyclic
chemistry 5. Methods in heterocyclic chemistry 6. Ring synthesis of
aromatic heterocycles 7. Typical reactivity of pyridines, quinolines and
isoquinolines 8. Pyridines: reactions and synthesis 9. Quinolines and
isoquinolines: reactions and synthesis 10. Typical reactivity of pyrylium
and benzopyrylium ions, pyrones and benzopyrones 11. Pyryliums, 2- and
4-pyrones: reactions and synthesis 12. Benzopyryliums, benzopyrones:
reactions and synthesis 13. Typical reactivity of the diazines: pyridazine,
pyrimidine and pyrazine 14. The diazines: pyridazine, pyrimidine, and
pyrazine: reactions and synthesis 15. Typical reactivity of pyrroles,
thiophenes, and furans 16. Pyrroles: reactions and synthesis 17.
Thiophenes: reactions and synthesis 18. Furans: reactions and synthesis 19.
Typical reactivity of indoles, benzo[b]thiophenes, benzo[b]furans,
isoindoles, benzo[c]thiophenes and isobenzofurans 20. Indoles: reactions
and synthesis 21. Benzo[b]thiophenes and benzo[b]furans: reactions and
synthesis 22. Isoindoles, benzo[c]thiophenes and isobenzofurans: reactions
and synthesis 23. Typical reactivity of 1,3- and 1,2-azoles and benzo-1,3-
and -1,2-azoles 24. 1,3-Azoles: imidazoles, thiazoles, and oxazoles:
reactions and synthesis 25. 1,2-Azoles: pyrazoles, isothiazoles,
isoxazoles: reactions and synthesis 26. Benzanellated azoles: reactions and
synthesis 27. Purines: reactions and synthesis 28. Heterocycles containing
a ring-junction nitrogen (bridgehead compounds) 29. Heterocycles containing
more than two heteroatoms 30. Saturated and partially unsaturated
heterocyclic compounds: reactions and synthesis 31. Special topics 32.
Heterocycles in biochemistry; heterocyclic natural products 33.
Heterocycles in medicine

Rezensionen

"This excellent book is well written, heavily referenced, and thoroughly indexed. Accordingly, it serves as both an instructional heterocyclic chemistry textbook and a portal to the primary synthetic chemistry literature." (Journal of Medicinal Chemistry, 2011)

"My favourite chapter is the organometallic chemistry that presents an up-to-date treatment of the topic and helps confirms a colleague's observation that 'With today's techniques one can be convinced that a modern organic chemist can make any small molecule he or she desires.' I particularly like the treatment of the concatenation of five-membered ring systems, an increasingly important area in medicinal chemistry. This chapter proves a real 'coup de grace'." (Reviews, December 2010)

"In summary, Heterocyclic Chemistry by Joule and Mills is in a class of its own and can be thoroughly recommended as supplementary reading for undergraduate courses and as a first port of call for researchers seeking a quick entry to the extensive heterocyclic literature." (Applied Organometallic Chemistry, 2010)

"My recommendation is, even if you already have the 4th edition, to buy the latest version. At only £39.95 for the paperback version this is outstanding value for money." (Organic Process Research & Development Journal, 2010)

"Overall, this book is recommended as a text for undergraduate and more advanced students on this pervasive, important, and underappreciated topic in chemistry." (Journal of Chemical Education, 1 October 2012)

"This excellent book is well written, heavily referenced, and thoroughly indexed. Accordingly, it serves as both an instructional heterocyclic chemistry textbook and a portal to the primary synthetic chemistry literature." (Journal of Medicinal Chemistry, 2011)

"My favourite chapter is the organometallic chemistry that presents an up-to-date treatment of the topic and helps confirms a colleague's observation that 'With today's techniques one can be convinced that a modern organic chemist can make any small molecule he or she desires.' I particularly like the treatment of the concatenation of five-membered ring systems, an increasingly important area in medicinal chemistry. This chapter proves a real 'coup de grace'." (Reviews, December 2010)

"In summary, Heterocyclic Chemistry by Joule and Mills is in a class of its own and can be thoroughly recommended as supplementary reading for undergraduate courses and as a first port of call for researchers seeking a quick entry to the extensive heterocyclic literature." (Applied Organometallic Chemistry, 2010)

"My recommendation is, even if you already have the 4th edition, to buy the latest version. At only £39.95 for the paperback version this is outstanding value for money." (Organic Process Research & Development Journal, 2010)