Table of contents:
Series Introduction (Samuel Z. Goldhaber)
Preface to Third Edition
Preface to Second Edition
Preface to First Edition
Contributors
History of Heparin-Induced Thrombocytopenia
Theodore E. Warkentin
Differential Diagnosis of Acute Thrombocytopenia
Volker Kiefel
Clinical Picture of Heparin-Induced Thrombocytopenia
Theodore E. Warkentin
Frequency of Heparin-Induced Thrombocytopenia
David H. Lee and Theodore E. Warkentin
Nonimmune Heparin-Platelet Interactions: Implications for the Pathogenesis of Heparin-Induced Thrombocytopenia
McDonald K. Horne III
Heparin-Dependent Antigens in Heparin-Induced Thrombocytopenia
Jean Amiral and Dominique Meyer
Molecular Immunopathogenesis of Heparin-Induced Thrombocytopenia
Gian Paolo Visentin, Chao Yan Liu, and Richard H. Aster
Role of Sulfated Polysaccharides in the Pathogenesis of Heparin-Induced Thrombocytopenia
Susanne Alban and Andreas Greinacher
The Platelet Fc Receptor in Heparin-Induced Thrombocytopenia
Gregory A. Denomme
Immune Vascular Injury in Heparin-Induced Thrombocytopenia
Gowthami M. Arepally, Mortimer Poncz, and Douglas B. Cines
Laboratory Testing for Heparin-Induced Thrombocytopenia
Theodore E. Warkentin and Andreas Greinacher
Pseudo-Heparin-Induced Thrombocytopenia
Theodore E. Warkentin
Treatment of Heparin-Induced Thrombocytopenia: An Overview
Andreas Greinacher and Theodore E. Warkentin
Danaparoid for the Treatment of Heparin-Induced Thrombocytopenia
Beng Hock Chong and Harry N. Magnani
Lepirudin for the Treatment of Heparin-Induced Thrombocytopenia
Andreas Greinacher
Agatroban Therapy in Heparin-Induced Thrombocytopenia
Bruce E. Lewis and Marcie J. Hursting
Bivalirudin for the Treatment of Heparin-Induced Thrombocytopenia
John R. Bartholomew
Hemodialysis in Heparin-Induced Thrombocytopenia
Karl-Georg Fischer
Management of Cardiopulmonary Bypass Anticoagulation in Patients with Heparin-Induced Thrombocytopenia
Bernd Poetzsch and Katharina Madlener
Heparin-Induced Thrombocytopenia in Children
Anne F. Klenner and Andreas Greinacher
Legal Aspects of Heparin-Induced Thrombocytopenia: U.S. Perspectives
Kevin M. McIntyre and Theodore E. Warkentin
Legal Aspects of Heparin-Induced Thrombocytopenia: European Perspectives
Klaus Ulsenheimer
Appendixes
1 Ten Clinical "Rules" for Diagnosing HIT
2 Estimating the Pretest Probability of HIT: The Four T's
3 Platelet Count Monitoring for HIT
4 Treatment Recommendations
5 Danaparoid Dosing Schedules in HIT Patients
6 Dosing Schedules for Lepirudin Treatment of Patients with HIT
7 Dosing Schedule for Lepirudin in Patients with HIT and Renal Impairment
8 Dosing Schedules for Argatroban Treatment of Patients with HIT (Approved Indications)
9 Timelines of an Episode of HIT
Index
Taking stock of advances in clinical recognition, laboratory testing, and pharmacologic therapy as well as basic aspects of pathogenesis, the Third Edition of Heparin-Induced Thrombocytopenia reinforces its standing as the leading guide to accurate diagnosis and effective management of this complex condition. Featuring added chapters on bivalirudin and pediatric heparin-induced thrombocytopenia (HIT), this reference also updates all 20 chapters of the previous edition to regard anew such topics as management of HIT using direct thrombin inhibitors and the special problems of renal failure and cardiac surgery in HIT patients.
This edition reinforces and updates the leading guide to accurate diagnosis and effective management of this complex condition. It is essential reading for all those studying and dealing with it.
Series Introduction (Samuel Z. Goldhaber)
Preface to Third Edition
Preface to Second Edition
Preface to First Edition
Contributors
History of Heparin-Induced Thrombocytopenia
Theodore E. Warkentin
Differential Diagnosis of Acute Thrombocytopenia
Volker Kiefel
Clinical Picture of Heparin-Induced Thrombocytopenia
Theodore E. Warkentin
Frequency of Heparin-Induced Thrombocytopenia
David H. Lee and Theodore E. Warkentin
Nonimmune Heparin-Platelet Interactions: Implications for the Pathogenesis of Heparin-Induced Thrombocytopenia
McDonald K. Horne III
Heparin-Dependent Antigens in Heparin-Induced Thrombocytopenia
Jean Amiral and Dominique Meyer
Molecular Immunopathogenesis of Heparin-Induced Thrombocytopenia
Gian Paolo Visentin, Chao Yan Liu, and Richard H. Aster
Role of Sulfated Polysaccharides in the Pathogenesis of Heparin-Induced Thrombocytopenia
Susanne Alban and Andreas Greinacher
The Platelet Fc Receptor in Heparin-Induced Thrombocytopenia
Gregory A. Denomme
Immune Vascular Injury in Heparin-Induced Thrombocytopenia
Gowthami M. Arepally, Mortimer Poncz, and Douglas B. Cines
Laboratory Testing for Heparin-Induced Thrombocytopenia
Theodore E. Warkentin and Andreas Greinacher
Pseudo-Heparin-Induced Thrombocytopenia
Theodore E. Warkentin
Treatment of Heparin-Induced Thrombocytopenia: An Overview
Andreas Greinacher and Theodore E. Warkentin
Danaparoid for the Treatment of Heparin-Induced Thrombocytopenia
Beng Hock Chong and Harry N. Magnani
Lepirudin for the Treatment of Heparin-Induced Thrombocytopenia
Andreas Greinacher
Agatroban Therapy in Heparin-Induced Thrombocytopenia
Bruce E. Lewis and Marcie J. Hursting
Bivalirudin for the Treatment of Heparin-Induced Thrombocytopenia
John R. Bartholomew
Hemodialysis in Heparin-Induced Thrombocytopenia
Karl-Georg Fischer
Management of Cardiopulmonary Bypass Anticoagulation in Patients with Heparin-Induced Thrombocytopenia
Bernd Poetzsch and Katharina Madlener
Heparin-Induced Thrombocytopenia in Children
Anne F. Klenner and Andreas Greinacher
Legal Aspects of Heparin-Induced Thrombocytopenia: U.S. Perspectives
Kevin M. McIntyre and Theodore E. Warkentin
Legal Aspects of Heparin-Induced Thrombocytopenia: European Perspectives
Klaus Ulsenheimer
Appendixes
1 Ten Clinical "Rules" for Diagnosing HIT
2 Estimating the Pretest Probability of HIT: The Four T's
3 Platelet Count Monitoring for HIT
4 Treatment Recommendations
5 Danaparoid Dosing Schedules in HIT Patients
6 Dosing Schedules for Lepirudin Treatment of Patients with HIT
7 Dosing Schedule for Lepirudin in Patients with HIT and Renal Impairment
8 Dosing Schedules for Argatroban Treatment of Patients with HIT (Approved Indications)
9 Timelines of an Episode of HIT
Index
Taking stock of advances in clinical recognition, laboratory testing, and pharmacologic therapy as well as basic aspects of pathogenesis, the Third Edition of Heparin-Induced Thrombocytopenia reinforces its standing as the leading guide to accurate diagnosis and effective management of this complex condition. Featuring added chapters on bivalirudin and pediatric heparin-induced thrombocytopenia (HIT), this reference also updates all 20 chapters of the previous edition to regard anew such topics as management of HIT using direct thrombin inhibitors and the special problems of renal failure and cardiac surgery in HIT patients.
This edition reinforces and updates the leading guide to accurate diagnosis and effective management of this complex condition. It is essential reading for all those studying and dealing with it.