This volume provides a comprehensive and state-of-the-art review on pediatric hematopoietic stem cell transplantation (HSCT). The book covers such topics as graft versus host disease (GVHD), HSC mobilization, stem cell selection, and HSCT-relevant laboratory assays and techniques. The text is specially formatted so that the scientific basis of HSCT and ethical considerations are integrated into the relevant clinical framework. Each chapter also includes diagrams, illustrations, and tables that summarize key points and concepts that can be used as a quick visual reference for the…mehr
This volume provides a comprehensive and state-of-the-art review on pediatric hematopoietic stem cell transplantation (HSCT). The book covers such topics as graft versus host disease (GVHD), HSC mobilization, stem cell selection, and HSCT-relevant laboratory assays and techniques. The text is specially formatted so that the scientific basis of HSCT and ethical considerations are integrated into the relevant clinical framework. Each chapter also includes diagrams, illustrations, and tables that summarize key points and concepts that can be used as a quick visual reference for the reader.
Written by experts in the field, Hematopoietic Stem Cell Transplantation for the Pediatric Hematologist/Oncologist is a valuable resource on pediatric HSCT suited for pediatric hematologists-oncologists, fellows, advanced practitioners, clinical nurses, and other referring physicians.
Valerie I. Brown, MD, PhD Director, Experimental Therapeutics, Pediatric Hematology/Oncology Director, Pediatric Hematology/Oncology Fellowship Program Penn State Milton S. Hershey Medical Center and Children's Hospital, Division of Pediatric Oncology/Hematology, Hershey, PA, USA
Inhaltsangabe
Part I. Introduction, History and the Basic Principles of Pediatric Hematopoietic Stem Cell Transplantation (HSCT)
1. IntroductionValerie I. Brown 2. Historical Overview of Pediatric HSCT Valerie I. Brown 3. Brief Introduction to the Basic Scientific Principles of Hematopoietic Stem Cell Transplantation (HSCT)Valerie I. Brown Part II. Topics Related to the Pre- HSCT Period 4. Pretransplantation: Indications and TimingAlicia McFarren and Michael A. Pulsipher 5. Spotlight on Minimal Residual Disease (MRD): Impact of MRD on HSCT Outcomes for Pediatric LeukemiaAbdel-Azim and Michael A. Pulsipher 6. HSCT Recipient Pretransplantation Evaluation Carrie Eichelberger and Valerie I. Brown 7. How to Select a Donor and Hematopoietic Stem Cell Source: Related versus Unrelated Donors for Allogeneic HSCT Malika Kapadia and Robert Greiner 8. Donor Evaluation, Selection and Hematopoietic Stem Cell Mobilization, Procurement and Manipulation William Ferguson and Aleksander Babic 9. Preparing the Patient for HSCT: Conditioning Regimens and their Scientific Rationale Carrie Kitko, Katie Gatwood, James Connelly Part III. The Peri- HSCT Period: Pre-Engraftment (Days 0-30) and Early Post- HSCT (Days 30-100) Periods 10. Engraftment and Chimerism Valerie I. Brown 11. Graft Failure Valerie I. Brown 12. Engraftment Syndrome and Associated Cytokine Storm and Capillary Leak Syndrome Mala K. Talekar and Jason L. Freedman 13. Nutrition in the Peri-HSCT Period Arun Gurunathan, Judy Bailer, Jason L. Freedman 14. Mucositis and Pain in the Peri- HSCT Period Arun Gurunathan, Neil S. Patel, Jason L. Freedman 15. Hepatoxicity in the Peri- HSCT Period Valerie I. Brown 16. Renal Toxicities in the Peri-HSCT PeriodMalika Kapadia, Terry Shapiro and Robert Greiner 17. Infectious Complications and HSCT Karen Bride, Ellen Levy, Anne Wohlschlaeger, Jason L. Freedman 18. Acute Graft-Versus-Host Disease: Diagnosis, Prophylaxis, and TreatmentKaren L. Bride, Neil S. Patel, Jason L. Freedman Part IV. The Late Post- HSCT Period (> 100 Days) 19. Chronic GVHD Terry Wikle Shapiro, Malika Kapadia 20. Hematologic Complications Associated with HSCT Mala K. Talekar and Timothy Olson 21. Pulmonary Complications Associated with HSCT Malika Kapadia and Terry Shapiro 22. Renal Complications Associated with HSCT Lena E. Winestone, Alix E. Seif, Benjamin L. Laskin 23. Cardiac Complications Associated with HSCT Valerie I. Brown 24. Neurologic and Sensory Complications Associated with HSCT Valerie I. Brown 25. HSCT-Associated Complications of the Skin, Hair and Nails Valerie I. Brown Part V: Life After HSCT 26. Immune Reconstitution after Hematopoietic Stem Cell Transplantation Mala K. Talekar and Timothy Olsen 27. Life After HSCT: Survivorship and Long-Term Issues Smita Dandekar Part VI. Pharmacologic-Related Issues of Pediatric HSCT 28. Medications commonly Used in Pediatric HSCT Kevin Mulieri, Ashley Teusink-Cross, JoEllen Wellnau, Krisoula Horiates, Katie S. Gatwood
Part I. Introduction, History and the Basic Principles of Pediatric Hematopoietic Stem Cell Transplantation (HSCT)
1. IntroductionValerie I. Brown 2. Historical Overview of Pediatric HSCT Valerie I. Brown 3. Brief Introduction to the Basic Scientific Principles of Hematopoietic Stem Cell Transplantation (HSCT)Valerie I. Brown Part II. Topics Related to the Pre- HSCT Period 4. Pretransplantation: Indications and TimingAlicia McFarren and Michael A. Pulsipher 5. Spotlight on Minimal Residual Disease (MRD): Impact of MRD on HSCT Outcomes for Pediatric LeukemiaAbdel-Azim and Michael A. Pulsipher 6. HSCT Recipient Pretransplantation Evaluation Carrie Eichelberger and Valerie I. Brown 7. How to Select a Donor and Hematopoietic Stem Cell Source: Related versus Unrelated Donors for Allogeneic HSCT Malika Kapadia and Robert Greiner 8. Donor Evaluation, Selection and Hematopoietic Stem Cell Mobilization, Procurement and Manipulation William Ferguson and Aleksander Babic 9. Preparing the Patient for HSCT: Conditioning Regimens and their Scientific Rationale Carrie Kitko, Katie Gatwood, James Connelly Part III. The Peri- HSCT Period: Pre-Engraftment (Days 0-30) and Early Post- HSCT (Days 30-100) Periods 10. Engraftment and Chimerism Valerie I. Brown 11. Graft Failure Valerie I. Brown 12. Engraftment Syndrome and Associated Cytokine Storm and Capillary Leak Syndrome Mala K. Talekar and Jason L. Freedman 13. Nutrition in the Peri-HSCT Period Arun Gurunathan, Judy Bailer, Jason L. Freedman 14. Mucositis and Pain in the Peri- HSCT Period Arun Gurunathan, Neil S. Patel, Jason L. Freedman 15. Hepatoxicity in the Peri- HSCT Period Valerie I. Brown 16. Renal Toxicities in the Peri-HSCT PeriodMalika Kapadia, Terry Shapiro and Robert Greiner 17. Infectious Complications and HSCT Karen Bride, Ellen Levy, Anne Wohlschlaeger, Jason L. Freedman 18. Acute Graft-Versus-Host Disease: Diagnosis, Prophylaxis, and TreatmentKaren L. Bride, Neil S. Patel, Jason L. Freedman Part IV. The Late Post- HSCT Period (> 100 Days) 19. Chronic GVHD Terry Wikle Shapiro, Malika Kapadia 20. Hematologic Complications Associated with HSCT Mala K. Talekar and Timothy Olson 21. Pulmonary Complications Associated with HSCT Malika Kapadia and Terry Shapiro 22. Renal Complications Associated with HSCT Lena E. Winestone, Alix E. Seif, Benjamin L. Laskin 23. Cardiac Complications Associated with HSCT Valerie I. Brown 24. Neurologic and Sensory Complications Associated with HSCT Valerie I. Brown 25. HSCT-Associated Complications of the Skin, Hair and Nails Valerie I. Brown Part V: Life After HSCT 26. Immune Reconstitution after Hematopoietic Stem Cell Transplantation Mala K. Talekar and Timothy Olsen 27. Life After HSCT: Survivorship and Long-Term Issues Smita Dandekar Part VI. Pharmacologic-Related Issues of Pediatric HSCT 28. Medications commonly Used in Pediatric HSCT Kevin Mulieri, Ashley Teusink-Cross, JoEllen Wellnau, Krisoula Horiates, Katie S. Gatwood
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