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A significant increase in the HSP 70 protein expression in the subjects doing regular deep breathing exercises especially Sudarshan Kriya Yoga has been observed. The expression of the same protein was comparable to the subjects living their life moderately i.e. who are not doing any kind of deep breathing exercises. Expression of HSP 70 was found to be increased significantly in all the age groups considered under study. In the present study, it was also observed that expression of HSP 70 depends upon the intensity and time duration of the exercises. Extracellular HSP 70 is present in both healthy as well as diseased subjects. HSP 70 plays dual role in the body as in the healthy it serves many different roles like in immune regulation as well as cytoprotective roles, whereas in case of diseased, extracellular HSP70 acts as a danger signal to immune cells, promote immune response and improves host defense. HSP comes out via cell lysis in case of diseased, whereas, in the healthy subjects doing regular physical activity it comes out via secretory pathways in which exosomes provide a secretory vesicle facilitating the exocytosis of HSP which is beneficial for the body.