In pathology, wound healing refers to healing of injured tissue by living tissue. A deep perception of clinical and biological variables affects the periodontal regeneration and allows the dental practitioner to redirect clinical and biological factors effectively to enhance clinical result and increase periodontal regeneration. Healing is ideal when there is acceptable aesthetics and appropriate function. Therefore, a meticulous knowledge regarding the relationship and nature of various periodontal tissues is needed to attain satisfactory healing which result in the development of new periodontal ligament, alveolar bone and cementum, and properly secured by gingival tissue.