This third edition of a classic volume contains contributions from experts who offer both fundamental and applied information. Providing a fresh perspective on several topics, this edition contains completely rewritten chapters on immunotoxicology, endocrine toxicology, and reproductive and developmental toxicology. It also presents several new chapters on topics including pharmaceutical toxicology, juvenile toxicology, and safety pharmacology. The format of the book is designed to allow working toxicologists to locate basic information quickly. A separate glossary is included with terms presented both alphabetically and by toxicological subspecialty.…mehr
This third edition of a classic volume contains contributions from experts who offer both fundamental and applied information. Providing a fresh perspective on several topics, this edition contains completely rewritten chapters on immunotoxicology, endocrine toxicology, and reproductive and developmental toxicology. It also presents several new chapters on topics including pharmaceutical toxicology, juvenile toxicology, and safety pharmacology. The format of the book is designed to allow working toxicologists to locate basic information quickly. A separate glossary is included with terms presented both alphabetically and by toxicological subspecialty.
Michael J. Derelanko, PhD, DABT, FATS, has spent most of his career as a toxicologist in the pharmaceutical and chemical industries. He most recently was director of nonclinical drug safety assessment for Adolor Corporation where he contributed to the discovery and development of novel drugs for nearly ten years. Prior to that, as manager of toxicology and risk assessment for Honeywell International, he supported the company's chemical businesses for over two decades. He currently is employed by Critical Path Services, a Knoell company, where he provides expertise in toxicology and hazard communication. Carol S. Auletta, DABT, RAC, MBA, has worked in toxicology research for more than 30 years. She is board certified in toxicology by the American Board of Toxicology and in regulatory affairs by the Regulatory Affairs Professionals Society. Carol has spent her career in the CRO industry and currently serves as a senior director in safety assessment and the director of program management at Huntingdon Life Sciences in East Millstone, New Jersey.
Inhaltsangabe
Laboratory Animal Management. General Toxicology. Dermal Toxicology. Ocular Toxicology. In Vitro Methods for the Prediction of Ocular and Dermal Toxicity. Inhalation Toxicology. Neurotoxicology. Immunotoxicology. Renal Toxicology. Developmental and Reproductive Toxicity. Juvenile Toxicology. Endocrine Toxicology. Genetic Toxicology. Carcinogenesis. Histopathology. Clinical Pathology. Metabolism and Toxicokinetics of Xenobiotics. Human Clinical Toxicology. Chemical Toxicology. Pharmaceutical Toxicology. Safety Pharmacology. Risk Assessment. Regulatory Toxicology. Appendix A: LD50 Values. Appendix B: Tables of Comparative Anatomical, Physiological, and Biochemical Data. Appendix C: Mathematics, Symbols, Physical Constants, Conversions, and Statistics. Appendix D: Calculations, Preparation, and Properties of Substances Used in Toxicology. Appendix E: Design and Performance of Toxicology Studies. Appendix F: Organizations and Agencies. Appendix G: Acronyms. Appendix H: Academic Programs in Toxicology. Appendix I: Physical/Chemical Information. Glossary. Index.
