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Handbook of Manufacturing and Supply Systems Design: From Strategy Formulation to System Operation proposes a conceptual MSM framework based on key principles of systems theory, which draws on the relevant methodologies and techniques set out in literature and on data gathered from industrial practice. The handbook describes how a prototype of this framework has been used in the structuring and implementation of a computer-aided manufacturing system design environment and the application of key aspects of this framework within industrial companies. Also included is a self-contained workbook, which provides a step-by-step guide through the complete cycle of management, design and operation.