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The present investigation on "Biology, varietal performance and management of lesser grain borer, Rhyzopertha dominica (Fab.) on wheat." its for biology of R. dominica. Amongs the twenty five wheat varieties screened against R. dominica, the varieties GW-322 and GW-366 were found tolerant, while MACS-6274 and AKOW-4021 were recorded to be susceptible to this pest. The effectiveness of some grain protectants against lesser grain borer, R. dominica in stored wheat indicated that the grain treated with deltamethrin 2.8 EC @ 1 ml/lit. water and malathion 1 ml/lit. water were found to be most effective in minimizing damage of R. dominica than the rest of treatments. These treatments recorded minimum grain damage and weight loss. Among the plant origin treatments, neem leaf powder @ 25 g/ kg seeds performed better. The mixing of these chemical and botanical grain protectants with wheat grains did not cause any adverse effect on seed germination.