This book focuses on the origin of GSH in the nervous system, the effects of GSH on neural health and activity, and the potential for alterations in GSH status to lead to neurological damage of the type observed in amyotrophic lateral sclerosis, Parkinson's disease, and other neurological disorders.
This book focuses on the origin of GSH in the nervous system, the effects of GSH on neural health and activity, and the potential for alterations in GSH status to lead to neurological damage of the type observed in amyotrophic lateral sclerosis, Parkinson's disease, and other neurological disorders.
1. Multiple Roles of Glutathione in the Nervous System Christopher Shaw 2. The Discovery of the GSH Receptor in Hydra and its Evolutionary Significance Howard Lenhoff 3. Carrier-Mediated GSH Transport at the Blood-Brain Barrier and Molecular Characterisation of Novel Brain GSH Transporters Ram Kannan Jian-R. Yi Berislav Zlokovic and Neil Kaplowitz 4. Antibodies to Glutathione: Production Characterisation and Immunocytochemical application to the Central Nervous System Ole Hjelle E. Rinvik D. Huster W. Reichelt and Ole Ottersen 5. Role of Astrocytes in Maintaining Cerebral Glutathione Homeostasis and in Protecting the Brain Against Xenobiotics and Oxidative Stress Arthur Cooper 6. Glutathione and the Regulation of Apoptosis in the Nervous System Khalequz Zaman and Rajiv Ratan 7. Possible Modulation by Glutathione of Glutamatergic Neurotransmission Kiyokazu Ogita Makato Shuto Hiriko Maeda Takao Minami and Yukio Yoneda 8. Glutathione and Glutathione Derivatives: Possible Modulators of Ionotropic Glutamate Receptors Reka Janaky Vince Varga Zsolt Jenei Pirjo Saransaari and Simo Oja 9. Excitatory Actions of GSH on Neocortex Bryce Pasqualotto Kenneth Curry and Christopher Shaw 10. Medicinal Chemistry of Glutathione and Glutathione Analogs in the Mammalian Central Nervous System Kenneth Curry 11. Glutathione in Brain Ageing and Neurodegenerative Disorders Gianni Benzi and Antonio Moretti 12. The Glutathione Redox State and Zinc Mobilisation from Metallothionein and other Proteins with Zinc-Sulphur Co-ordination Sites Wolfgang Maret 13. Glutathione Release and Nitrosoglutathione Presence in the CNS: Implications for Schizophrenia Michel Cuenod and Kim Quang Do 14. The Role of Altered Glutathione Status in the Development of Parkinson's Disease J. Sian M. Gerlach and P. Riederer 15. Glutathione Cysteine and the Neuromelanin Pathway: Potential Roles in the Pathogenesis of Parkinson's Disease - a New Hypothesis Glenn Dryhurst 16. Free-Radical Toxicity in Amyotrophic Lateral Sclerosis Merit Cudkowicz Robert Brown and Richard Smith 17. Oxidative Stress and Neurological Diseases: Is Glutathione Depletion a Common Factor? Jaswinder Bains and Christopher Shaw. Gianni Benzi University of Pavia Italy Robert Brown Massachusetts General Hospital USA Arthur Cooper Cornell University Medical College Merit Cudkowicz Massachusetts General Hospital USA Michel Cuenod University of Zurich Switzerland Kenneth Curry Precision Biochemicals Inc. Canada Kim Quang Do University of Zurich Switzerland Glenn Dryhurst University of Oklahoma USA M. Gerlach University of Bochum Germany Ole Hjelle University of Oslo Norway D. Huster University of Leipzig Germany Reka Janaky University of Tampere Medical School Finland Zsolt Jenei University of Tampere Medical School Finland Ram Kannan USC School of Medicine USA Neil Kaplowitz USC School of Medicine USA Howard Lenhoff University of California USA Hiroko Maeda Setsunan University Japan Wolfgang Maret Harvard Medical School USA Takao Minami Setsunan University Japan Antonio Moretti University of Pavia Italy Kiyokazu Ogita Setsunan University Japan Simo Oja University of Tampere Medical School Finland Ole Ottersen University of Oslo Norway Bryce Pasqualotto University of British Columbia Canada Rajiv Ratan Harvard Institutes of Medicine USA W. Reichelt University of Leipzig Germany P. Reiderer University of Wurzburg Germany E. Rinvik University of Oslo Norway Pirjo Saransaari University of Tampere Medical School Finland Christopher Shaw University of British Columbia Canada Makoto Shuto Setsunan University Japan J. Sian University of Wurzburg Germany Richard Smith The Centre for Neurologic Study USA Vince Varga University of Tampere Medical School Finland Jian-R. Yi USC School of Medicine USA Yukio Yoneda Setsunan University Japan Khalequz Zaman Harvard Institutes of Medicine USA Berislav Zlokovic USC School of Medicine USA.
1. Multiple Roles of Glutathione in the Nervous System Christopher Shaw 2. The Discovery of the GSH Receptor in Hydra and its Evolutionary Significance Howard Lenhoff 3. Carrier-Mediated GSH Transport at the Blood-Brain Barrier and Molecular Characterisation of Novel Brain GSH Transporters Ram Kannan Jian-R. Yi Berislav Zlokovic and Neil Kaplowitz 4. Antibodies to Glutathione: Production Characterisation and Immunocytochemical application to the Central Nervous System Ole Hjelle E. Rinvik D. Huster W. Reichelt and Ole Ottersen 5. Role of Astrocytes in Maintaining Cerebral Glutathione Homeostasis and in Protecting the Brain Against Xenobiotics and Oxidative Stress Arthur Cooper 6. Glutathione and the Regulation of Apoptosis in the Nervous System Khalequz Zaman and Rajiv Ratan 7. Possible Modulation by Glutathione of Glutamatergic Neurotransmission Kiyokazu Ogita Makato Shuto Hiriko Maeda Takao Minami and Yukio Yoneda 8. Glutathione and Glutathione Derivatives: Possible Modulators of Ionotropic Glutamate Receptors Reka Janaky Vince Varga Zsolt Jenei Pirjo Saransaari and Simo Oja 9. Excitatory Actions of GSH on Neocortex Bryce Pasqualotto Kenneth Curry and Christopher Shaw 10. Medicinal Chemistry of Glutathione and Glutathione Analogs in the Mammalian Central Nervous System Kenneth Curry 11. Glutathione in Brain Ageing and Neurodegenerative Disorders Gianni Benzi and Antonio Moretti 12. The Glutathione Redox State and Zinc Mobilisation from Metallothionein and other Proteins with Zinc-Sulphur Co-ordination Sites Wolfgang Maret 13. Glutathione Release and Nitrosoglutathione Presence in the CNS: Implications for Schizophrenia Michel Cuenod and Kim Quang Do 14. The Role of Altered Glutathione Status in the Development of Parkinson's Disease J. Sian M. Gerlach and P. Riederer 15. Glutathione Cysteine and the Neuromelanin Pathway: Potential Roles in the Pathogenesis of Parkinson's Disease - a New Hypothesis Glenn Dryhurst 16. Free-Radical Toxicity in Amyotrophic Lateral Sclerosis Merit Cudkowicz Robert Brown and Richard Smith 17. Oxidative Stress and Neurological Diseases: Is Glutathione Depletion a Common Factor? Jaswinder Bains and Christopher Shaw. Gianni Benzi University of Pavia Italy Robert Brown Massachusetts General Hospital USA Arthur Cooper Cornell University Medical College Merit Cudkowicz Massachusetts General Hospital USA Michel Cuenod University of Zurich Switzerland Kenneth Curry Precision Biochemicals Inc. Canada Kim Quang Do University of Zurich Switzerland Glenn Dryhurst University of Oklahoma USA M. Gerlach University of Bochum Germany Ole Hjelle University of Oslo Norway D. Huster University of Leipzig Germany Reka Janaky University of Tampere Medical School Finland Zsolt Jenei University of Tampere Medical School Finland Ram Kannan USC School of Medicine USA Neil Kaplowitz USC School of Medicine USA Howard Lenhoff University of California USA Hiroko Maeda Setsunan University Japan Wolfgang Maret Harvard Medical School USA Takao Minami Setsunan University Japan Antonio Moretti University of Pavia Italy Kiyokazu Ogita Setsunan University Japan Simo Oja University of Tampere Medical School Finland Ole Ottersen University of Oslo Norway Bryce Pasqualotto University of British Columbia Canada Rajiv Ratan Harvard Institutes of Medicine USA W. Reichelt University of Leipzig Germany P. Reiderer University of Wurzburg Germany E. Rinvik University of Oslo Norway Pirjo Saransaari University of Tampere Medical School Finland Christopher Shaw University of British Columbia Canada Makoto Shuto Setsunan University Japan J. Sian University of Wurzburg Germany Richard Smith The Centre for Neurologic Study USA Vince Varga University of Tampere Medical School Finland Jian-R. Yi USC School of Medicine USA Yukio Yoneda Setsunan University Japan Khalequz Zaman Harvard Institutes of Medicine USA Berislav Zlokovic USC School of Medicine USA.
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