Department of Medicine, University College London Medical School, The Rayne Institute, London, UK (address from October 1997: Wessex Human Genetics Institute, Southampton University Hospital, Southampton, UK). Department of Medicine, University College London Medical School, The Rayne Institute, London, UK.
Inhaltsangabe
Contributors Abbreviations Preface 1 Perspectives in human linkage studies. /S. Povey Pairwise linkage analysis of Mendelian traits Finding the cause of a disease which shows clear Mendelian inheritance After a LOO score of +3, what next? Narrowing the search by searching for critical recombinants Linkage disequilibrium Linkage analysis in more complex situations Linkage in complex traits Why are we doing this? References 2 Twin research: nature versus nurture in common diseases. /K.O. Kyvik Introduction History Biology of twinning Demography Twin studies Assumptions T he concept of concordance rates Heritability Twin studies and common diseases Other types of twin studies Conclusion References 3 The molecular basis of genetic variation: mutation detection methodologies and limitations. /E. Spanakis and I.N.M. Day Introduction Current theories of mutation Parallel development of theory with methodology Methods of mutation detection Limitations of current methods for mutation detection Our approaches Conclusions References 4 Finding susceptibility genes for schizophrenia. /M.J. Owen and M.C. O'Donovan Introduction Molecular genetic approaches to schizophrenia Candidate gene association studies Conclusions References 5 Approaches to determining the genetic basis of noninsulin dependent diabetes mellitus. /M. McCarthy Non insulin dependent diabetes mellitus (NIDDM) Overview of approaches to dissect NIDDM Choosing a candidate gene Exploring candidate genes Assessing genotype phenotype correlations Understanding the biology of complex traits References 6 Population scale genotype assays: APOE gene in Alzheimer's dementia and coronary risk. /I.N.M. Day, D. Palamand and E. Spanakis Introduction: availability of population scale gene testing Background Some future possibilities References 7 Genetic tests for corona
Contributors Abbreviations Preface 1 Perspectives in human linkage studies. /S. Povey Pairwise linkage analysis of Mendelian traits Finding the cause of a disease which shows clear Mendelian inheritance After a LOO score of +3, what next? Narrowing the search by searching for critical recombinants Linkage disequilibrium Linkage analysis in more complex situations Linkage in complex traits Why are we doing this? References 2 Twin research: nature versus nurture in common diseases. /K.O. Kyvik Introduction History Biology of twinning Demography Twin studies Assumptions T he concept of concordance rates Heritability Twin studies and common diseases Other types of twin studies Conclusion References 3 The molecular basis of genetic variation: mutation detection methodologies and limitations. /E. Spanakis and I.N.M. Day Introduction Current theories of mutation Parallel development of theory with methodology Methods of mutation detection Limitations of current methods for mutation detection Our approaches Conclusions References 4 Finding susceptibility genes for schizophrenia. /M.J. Owen and M.C. O'Donovan Introduction Molecular genetic approaches to schizophrenia Candidate gene association studies Conclusions References 5 Approaches to determining the genetic basis of noninsulin dependent diabetes mellitus. /M. McCarthy Non insulin dependent diabetes mellitus (NIDDM) Overview of approaches to dissect NIDDM Choosing a candidate gene Exploring candidate genes Assessing genotype phenotype correlations Understanding the biology of complex traits References 6 Population scale genotype assays: APOE gene in Alzheimer's dementia and coronary risk. /I.N.M. Day, D. Palamand and E. Spanakis Introduction: availability of population scale gene testing Background Some future possibilities References 7 Genetic tests for corona
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