This title provides an extremely helpful analysis of genes that may be associated with autoimmunity, and answers questions such as how these genes can be identified, and how the functions of the gene products can be elucidated. Incorporating data on disease-associated chromosomal loci that has been accumulated from inbred mice, the title: _ descibes how some susceptibility loci may be common to many diseases, whereas others are relatively disease specific _ discusses the importance of developing criteria for establishing the significance of these different categories of disease-associated loci.…mehr
This title provides an extremely helpful analysis of genes that may be associated with autoimmunity, and answers questions such as how these genes can be identified, and how the functions of the gene products can be elucidated.
Incorporating data on disease-associated chromosomal loci that has been accumulated from inbred mice, the title: _ descibes how some susceptibility loci may be common to many diseases, whereas others are relatively disease specific _ discusses the importance of developing criteria for establishing the significance of these different categories of disease-associated loci.
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Inhaltsangabe
Symposiumon Genomics of autoimmunity held at the Novartis Foundation London 22-24 June 2004. Editors: Gregory Bock (Organizer) and Jamie Goode. This symposium is based on a proposal by Abul Abbas David Hafler and John Rioux. Abbul Abbas: Chair's introduction. Mark Daly: Patterns of genetic variation in humans and mice. Discussion. David B. Goldstein: Haplotype tagging in pharmacogenetics. Discussion. Simon J. Foote Justin P. Rubio Melanie Bahlo Trevor J. Kilpatrick Terence P. Speed Jim Stankovich Rachel Burfoot Helmut Butzkueven Laura Johnson Chris Wilkinson Bruce Taylor Michele Sale Ingrid A. F. van derMei Joanne L. Dickinson and Patricia Groom: Multiple sclerosis: a haplotype association study. Discussion. Juha Kere: Mapping genes for asthma and psoriasis. Discussion. Linda S. Wicker Carolyn L. Moule Heather Fraser Carlos Penha-Goncalves Dan Rainbow Valerie E. S. Garner Giselle Chamberlain Kara Hunter Sarah Howlett Jan Clark Andrea Gonzalez-Munoz Anne Marie Cumiskey Paul Ti¡en Joanna Howson Barry Healy Luc J. Smink Amanda Kingsnorth Paul A. Lyons Simon Gregory Jane Rogers John A.Todd and Laurence B. Peterson: Natural genetic variants influencing type 1 diabetes in humans and in the NOD mouse. Discussion. Srividya Subramanian and Edward K. Wakeland: The importance of epistatic interactions in the development of autoimmunity. Discussion. Timothy J. Vyse Angela Richardson EmilyWalsh Lisa Farwell MarkJ. Daly Cox Terhorst and John D. Rioux: Mapping autoimmune disease genes in humans: lessons from IBD and SLE. Discussion. Cisca Wijmenga and Martin C. Wapenaar: A combined genetics and genomics approach to unravelling molecular pathways in coeliac disease. Discussion. Timothy W. Behrens Robert R. Graham Chieko Kyogoku Emily C. Baechler Paula S. Ramos Clarence Gillett Jason Bauer Ward A. Ortmann Keli L. Hippen Erik Peterson Carl D. Langefeld Kathy L.Moser Patrick M. Ga¡neyand Peter K. Gregersen: Progress towards understanding the genetic pathogenesis of systemic lupus erythematosus. Discussion. Vigo Heissmeyer Fernando Maciä n Rajat Varma Sin-Hyeog Im Francisco García-Cozar Heidi F.Horton Michael C. Byrne Stefan Feske K. Venuprasad Hua Gu Yun-Cai Liu Michael L. Dustin and Anjana Rao: A molecular dissection of lymphocyte unresponsiveness induced by sustained calcium signaling. Discussion. Adrian Liston and Christopher C. Goodnow: Genetic lesions in thymicTcell clonal deletion and thresholds for autoimmunity. Discussion. Lalitha Vijayakrishnan Jacqueline M. Slavik Zsolt Illés Dan Rainbow Laurence B. Peterson Arlene S. Sharpe Linda S. Wickerand Vijay K. Kuchroo: An autoimmune disease-associated CTLA4 splice variant lacking the B7 binding domain signals negatively in Tcells. Discussion. Adrian Ting Stefan Lichtenthaler Ramnik Xavier Soon-Young Na Shahrooz Rabizadeh TaraHolmes and Brian Seed: Large-scale screens for cDNAs with in vivo activity. Discussion. Jenny Ting: Genomic mining of new genes and pathways in innate and adaptive Immunity. Discussion. Index of contributors. Subject index.
Symposiumon Genomics of autoimmunity held at the Novartis Foundation London 22-24 June 2004. Editors: Gregory Bock (Organizer) and Jamie Goode. This symposium is based on a proposal by Abul Abbas David Hafler and John Rioux. Abbul Abbas: Chair's introduction. Mark Daly: Patterns of genetic variation in humans and mice. Discussion. David B. Goldstein: Haplotype tagging in pharmacogenetics. Discussion. Simon J. Foote Justin P. Rubio Melanie Bahlo Trevor J. Kilpatrick Terence P. Speed Jim Stankovich Rachel Burfoot Helmut Butzkueven Laura Johnson Chris Wilkinson Bruce Taylor Michele Sale Ingrid A. F. van derMei Joanne L. Dickinson and Patricia Groom: Multiple sclerosis: a haplotype association study. Discussion. Juha Kere: Mapping genes for asthma and psoriasis. Discussion. Linda S. Wicker Carolyn L. Moule Heather Fraser Carlos Penha-Goncalves Dan Rainbow Valerie E. S. Garner Giselle Chamberlain Kara Hunter Sarah Howlett Jan Clark Andrea Gonzalez-Munoz Anne Marie Cumiskey Paul Ti¡en Joanna Howson Barry Healy Luc J. Smink Amanda Kingsnorth Paul A. Lyons Simon Gregory Jane Rogers John A.Todd and Laurence B. Peterson: Natural genetic variants influencing type 1 diabetes in humans and in the NOD mouse. Discussion. Srividya Subramanian and Edward K. Wakeland: The importance of epistatic interactions in the development of autoimmunity. Discussion. Timothy J. Vyse Angela Richardson EmilyWalsh Lisa Farwell MarkJ. Daly Cox Terhorst and John D. Rioux: Mapping autoimmune disease genes in humans: lessons from IBD and SLE. Discussion. Cisca Wijmenga and Martin C. Wapenaar: A combined genetics and genomics approach to unravelling molecular pathways in coeliac disease. Discussion. Timothy W. Behrens Robert R. Graham Chieko Kyogoku Emily C. Baechler Paula S. Ramos Clarence Gillett Jason Bauer Ward A. Ortmann Keli L. Hippen Erik Peterson Carl D. Langefeld Kathy L.Moser Patrick M. Ga¡neyand Peter K. Gregersen: Progress towards understanding the genetic pathogenesis of systemic lupus erythematosus. Discussion. Vigo Heissmeyer Fernando Maciä n Rajat Varma Sin-Hyeog Im Francisco García-Cozar Heidi F.Horton Michael C. Byrne Stefan Feske K. Venuprasad Hua Gu Yun-Cai Liu Michael L. Dustin and Anjana Rao: A molecular dissection of lymphocyte unresponsiveness induced by sustained calcium signaling. Discussion. Adrian Liston and Christopher C. Goodnow: Genetic lesions in thymicTcell clonal deletion and thresholds for autoimmunity. Discussion. Lalitha Vijayakrishnan Jacqueline M. Slavik Zsolt Illés Dan Rainbow Laurence B. Peterson Arlene S. Sharpe Linda S. Wickerand Vijay K. Kuchroo: An autoimmune disease-associated CTLA4 splice variant lacking the B7 binding domain signals negatively in Tcells. Discussion. Adrian Ting Stefan Lichtenthaler Ramnik Xavier Soon-Young Na Shahrooz Rabizadeh TaraHolmes and Brian Seed: Large-scale screens for cDNAs with in vivo activity. Discussion. Jenny Ting: Genomic mining of new genes and pathways in innate and adaptive Immunity. Discussion. Index of contributors. Subject index.
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