Genes, Development and Cancer

The Life and Work of Edward B. Lewis
Herausgegeben:Lipshitz, Howard D.

• Broschiertes Buch

Produktbeschreibung

- For the first time, Nobel Prize winner, Edward B. Lewis' research papers are published within one volume

- Papers are organized into sections that reflect the focus of the research

- Commentaries by Howard Lipshitz highlight key methods and results by explaining the science so it is accessible to upper-level undergraduates, graduate students, and professional researchers

Produktdetails

• Verlag: Springer / Springer US / Springer, Berlin
• Softcover reprint of the original 1st ed. 2004
• Seitenzahl: 576
• Erscheinungstermin: 22. November 2012
• Englisch
• Abmessung: 235mm x 155mm x 31mm
• Gewicht: 872g
• ISBN-13: 9781461347460
• ISBN-10: 1461347467
• Artikelnr.: 39612965

Inhaltsangabe

Background -Invention of the cis-trans test for position effects -Position pseudoalleles -The bithorax pseudoalleles and the concept of developmental control -Gene evolution by tandem duplication -From cisvection to transvection- Extending the bithorax pseudoallelic series -Genetic versus functional models -From genes to gene complexes -Developmental genetics -Gain-of-function and loss-of-function alleles, and the operon model -Genetic mosaics: spatial and temporal aspects of bithorax function -The 1978 paper: a paradigm for the genetic control of development -Trans-acting regulators: positive and negative control of the homeotic complexes -Cis-regulation within the BX-C: the rules of engagement -Positional cloning of the BX-C -Completing the bithorax mutant series -The molecular basis of developmental control -Bithorax and the evolution of sexually dimorphic traits -DNA sequence motifs in the cis-regulatory regions of the BX-C -Evolution of the HOX complexes -Genetic and somatic effects of ionizing radiation -The political and social context -Leukemia and ionizing radiation -Political fallout -Thyroid radiation doses from weapons fallout -Best estimates of risk: leukemia in populations exposed to low doses of radiation -Estimates of lung cancer risk: the Batelle beagles