Introduction Overview of Viral and Non-Viral Vector Technologies DNA Integration for Monitoring Outcome in Gene Therapy Multiple Treatment Cycles and Gene Therapy RNA interference-based therapy for cancer Targeted systemic delivery of therapeutic siRNA Lentiviral-vector Common Integration Sites Selective Replicating Adenovirus and Tumor Necrosis Cancer Suicide Gene Therapy Adenovirus-retrovirus Hybrid Vectors Electroporation gene therapy Biomaterials-based technologies for therapeutics and imaging RNA Inhibition gene therapy Monocytogenes-based DNA Delivery System Toxin based Cancer Gene Therapy Overview: Rationale use of oncolytic virus in clinical applications Clinical development directions in oncolytic viral therapy Selectively replicating herpes simplex viral vector Oncolytic Vaccinia Virus for Cancer Therapy Lister strain Vaccinia Virus Modification of Mammalian Reoviruses Systemic Delivery of Oncolytic adenoviruses HIF-activated Oncolytic Adenoviruses Overview of Immune Targets and Pathways Overview of Gene Therapy with Gene-modified T Cells Genetically Engineered (TCR) T cells for adoptive therapy Viral-based Strategies for Combined Vaccine/microenvironment Modulation Dendritic Cell Vaccines Recombinant Poxvirus Vaccines Provenge® and Genetic Fusion Vaccines Lentivector Vaccines In vivo Immune Gene Therapy of Solid Tumours Chemotherapy Delivered after Viral Immunogene Therapy Overview: selecting effective targets for gene therapy of cancer Targeting Telomerase-expressing Cancer Cells Adenovirus-mediated shRNAs Adenovirus-mediated SOCS3 Gene Transfer p53-based Cancer Therapy Strategies for tumor-directed delivery of siRNA Overview of Drug Resistance and Manipulation Clinical Trials using LV P140KMGMT for Gliomas Delivery of Liposome-mediated MGMT-siRNA Cytidine Deaminase Gene Therapy for Recurrent Cancer Tissue Specific Gene Therapy Radiation Therapy Overview of angiogenesis and target identification Combination of Notch and Ephrin- targeted Therapy Effects of sustained VEGF blockade on the tumor microenvironment Clinical studies of Aflibercept (VEGF Trap) Overview of Molecular Imaging Strategies Using Gene-based Vectors NIS for Radio Gene Therapy Genetically Engineered Salmonella NIS Imaging in Cancer Targeted systemic gene therapy and molecular imaging Issues and Solutions in Moving Gene-therapy Approaches in Early Phase Trials Safety and Innovation in Cancer Gene Therapy Issues and Solutions in Moving Gene-therapy Approaches to Late-phase Trials FDA Review Process for Cancer Gene Therapy
Introduction Overview of Viral and Non-Viral Vector Technologies DNA Integration for Monitoring Outcome in Gene Therapy Multiple Treatment Cycles and Gene Therapy RNA interference-based therapy for cancer Targeted systemic delivery of therapeutic siRNA Lentiviral-vector Common Integration Sites Selective Replicating Adenovirus and Tumor Necrosis Cancer Suicide Gene Therapy Adenovirus-retrovirus Hybrid Vectors Electroporation gene therapy Biomaterials-based technologies for therapeutics and imaging RNA Inhibition gene therapy Monocytogenes-based DNA Delivery System Toxin based Cancer Gene Therapy Overview: Rationale use of oncolytic virus in clinical applications Clinical development directions in oncolytic viral therapy Selectively replicating herpes simplex viral vector Oncolytic Vaccinia Virus for Cancer Therapy Lister strain Vaccinia Virus Modification of Mammalian Reoviruses Systemic Delivery of Oncolytic adenoviruses HIF-activated Oncolytic Adenoviruses Overview of Immune Targets and Pathways Overview of Gene Therapy with Gene-modified T Cells Genetically Engineered (TCR) T cells for adoptive therapy Viral-based Strategies for Combined Vaccine/microenvironment Modulation Dendritic Cell Vaccines Recombinant Poxvirus Vaccines Provenge® and Genetic Fusion Vaccines Lentivector Vaccines In vivo Immune Gene Therapy of Solid Tumours Chemotherapy Delivered after Viral Immunogene Therapy Overview: selecting effective targets for gene therapy of cancer Targeting Telomerase-expressing Cancer Cells Adenovirus-mediated shRNAs Adenovirus-mediated SOCS3 Gene Transfer p53-based Cancer Therapy Strategies for tumor-directed delivery of siRNA Overview of Drug Resistance and Manipulation Clinical Trials using LV P140KMGMT for Gliomas Delivery of Liposome-mediated MGMT-siRNA Cytidine Deaminase Gene Therapy for Recurrent Cancer Tissue Specific Gene Therapy Radiation Therapy Overview of angiogenesis and target identification Combination of Notch and Ephrin- targeted Therapy Effects of sustained VEGF blockade on the tumor microenvironment Clinical studies of Aflibercept (VEGF Trap) Overview of Molecular Imaging Strategies Using Gene-based Vectors NIS for Radio Gene Therapy Genetically Engineered Salmonella NIS Imaging in Cancer Targeted systemic gene therapy and molecular imaging Issues and Solutions in Moving Gene-therapy Approaches in Early Phase Trials Safety and Innovation in Cancer Gene Therapy Issues and Solutions in Moving Gene-therapy Approaches to Late-phase Trials FDA Review Process for Cancer Gene Therapy
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