G Protein Coupled Receptors

Modeling, Activation, Interactions and Virtual Screening Volume 522
Herausgegeben:Conn, P. Michael

• Gebundenes Buch

Produktbeschreibung

This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers G protein coupled receptors, and includes chapters on such topics as GPCR modelling, interactions with other molecules, virtual screening and GPCR activation.

Produktdetails

• Methods in Enzymology Volume 522
• Verlag: Academic Press / Elsevier Science & Technology
• Artikelnr. des Verlages: C2012-0-03636-8
• Seitenzahl: 528
• Erscheinungstermin: 22. Februar 2013
• Englisch
• Abmessung: 28mm x 150mm x 229mm
• Gewicht: 965g
• ISBN-13: 9780124078659
• ISBN-10: 0124078656
• Artikelnr.: 37042840

Inhaltsangabe

GPCR Modeling

1. The Protein Local Optimization Program and G-Protein Coupled Receptors: Loop Restoration and Applications to Homology Modeling
2. Modeling Active GPCR Conformations
3. Molecular Modeling of Adenosine Receptors
4. Predicting G Protein-Coupled Receptors Families using Different Physiochemical Properties and Pseudo Amino Acid Composition


Computational Design and Experimental Characterization of GPCR Segment Models

GPCR Interactions with Other Molecules and Cross-Talk


5. G Protein-Coupled Receptor Interaction with Small GTPases
6. Quantification of Receptor Tyrosine Kinase Activation and Transactivation by G Protein Coupled Receptors Using Spatial Intensity Distribution Analysis (SpIDA)
7. NMR Methods for Detection of Small Molecule Binding to RGS4
8. Group II Activators of G-protein Signaling: Monitoring the Interaction of Ga with the G-Protein Regulatory Motif in the Intact Cell
9. Homogeneous Time-Resolved Fluorescence Assay to Probe Folded G Protein-Coupled Receptors
10. cAMP Biosensors Applied in Molecular Pharmacological Studies of G Protein-Coupled Receptors
11. Rhodopsin-Lipid Interactions Studied by NMR


GPCR Bias


12. Biasing the Parathyroid Hormone Receptor: Relating In Vitro Ligand Efficacy to In Vivo Biological Activity


Virtual Screening


13. Application of Monte Carlo-based Receptor-Ensemble Docking to Virtual Screening for GPCR Ligands
14. From Heptahelical Bundle to Hits from the Haystack: Structure-Based Virtual Screening for GPCR Ligands


GPCR Activation


15. Kinetics and Dynamics in the G-Protein Coupled Receptor Signaling Cascade
16. Magic Angle Spinning Nuclear Magnetic Resonance Spectroscopy of G Protein-Coupled Receptors
17. Post-Translation Modification of G Protein-Coupled Receptor in Relationship to Biased Agonism
18. Protein S-Nitrosylation Measurement