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The last ten years have shown a dramatic revolution in our understanding of early animal development. This new edition of the successful first edition describes the result of this revolution and explains how the body plan of an embryo emerges from the newly fertilised egg. The book starts with a critical discussion of embryological concepts and explains in simple terms the mathematics of cell states, morphogen gradients and threshold responses. The experimental evidence on the mechanism of regional specification in Xenopus, molluscs, annelids, ascidians as well as Caenorhabditis, the mouse, the chick and Drosophila is then discussed. The whole chapter devoted to the exciting developments in Drosophila provides a clear guide to the subject, including a new table outlining the developmentally important genes. The emphasis throughout is on conceptual clarity and unity: bringing together the mathematical models, embryological experiments and molecular biology into a single, comprehensive coherent account.
Table of contents:
Preface to the second edition; 1. Regional specification in animal development; 2. The concepts of experimental embryology; 3. Theoretical embryology; 4. Hierarchies of developmental decisions; 5. Development with a small cell number; 6. Models for man: the mouse and the chick; 7. The breakthrough; 8. What does it all mean?; Appendix: How to write a program for development.
In the last ten years there has been a revolution in our understanding of early animal development. This latest edition explains how the body plan of an embryo emerges from a newly fertilised egg. The emphasis is on conceptual clarity and unity ñ bringing together mathematical models, embryological experiments and molecular biology.
Describes our understanding of early animal development and explains how the body plan of an embryo emerges from the newly fertilised egg.
Table of contents:
Preface to the second edition; 1. Regional specification in animal development; 2. The concepts of experimental embryology; 3. Theoretical embryology; 4. Hierarchies of developmental decisions; 5. Development with a small cell number; 6. Models for man: the mouse and the chick; 7. The breakthrough; 8. What does it all mean?; Appendix: How to write a program for development.
In the last ten years there has been a revolution in our understanding of early animal development. This latest edition explains how the body plan of an embryo emerges from a newly fertilised egg. The emphasis is on conceptual clarity and unity ñ bringing together mathematical models, embryological experiments and molecular biology.
Describes our understanding of early animal development and explains how the body plan of an embryo emerges from the newly fertilised egg.