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We intended desired ointment developed for bacterial infection. So Levofloxacin is a fluoroquinolones of antibacterial drug effective in the treatement of bacterial conjuctivitis, sinus, kidney, bladder or prostate Here the main objective of the present work is besides delivering drug to the body, A drug delivery system to improve patient complance and dispersible are no exception. So we are select the topical drug delivery system by using formulation of ointment. The Levofloxacin ointment is prepared by the two ointment bases namely Olegogenous and Emulsion bases.