Formulation & Evaluation in-situ gel of Rizatriptan Benzoate by QbD

Formulation & Evaluation in-situ gel of Rizatriptan Benzoate by QbD

Antimigran In-situ Gel of Rizatriptan Benzoate

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Chemically Rizatriptan Benzoate is the N, N-diethyl -5(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine mono benzoate and is a selective 5-hydroxytriptamin[5-HT] 1B/1D receptor agonist. It has a weak affinity for other 5-HT receptor subtype and was launched in 1998 for the acute treatment of migraine in adults. It has good water solubility (42mg/ml) and poor bioavailability [45%] due to hepatic first pass effect. The suggested mechanism of anti-migraine action of Rizatriptan Benzoate is through activation of post synaptic 5-HT 1B receptor within cerebral and Dural vessel walls, causing vaso...