Exploring the Role of miRNAs in Human Cancer - Karaayvaz, Mihriban
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Unraveling the role of microRNAs in cancer has gained growing interest in the last few years. In this study, we identified miR-215 as a potential prognostic biomarker and miR-129 as a potential tumor suppressor and a novel therapeutic target in colorectal cancer. We showed that miR-215 levels were significantly decreased in tumors compared with corresponding normal tissues in patients diagnosed with stage II or stage III colorectal cancer. Furthermore, we described a novel mechanism mediated by miR-129 to trigger apoptosis by suppressing a key anti-apoptotic protein, BCL2. The expression of…mehr

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Produktbeschreibung
Unraveling the role of microRNAs in cancer has gained growing interest in the last few years. In this study, we identified miR-215 as a potential prognostic biomarker and miR-129 as a potential tumor suppressor and a novel therapeutic target in colorectal cancer. We showed that miR-215 levels were significantly decreased in tumors compared with corresponding normal tissues in patients diagnosed with stage II or stage III colorectal cancer. Furthermore, we described a novel mechanism mediated by miR-129 to trigger apoptosis by suppressing a key anti-apoptotic protein, BCL2. The expression of miR-129 was significantly and progressively down regulated in colorectal cancer tissue specimens compared with the adenomas and normal control samples. More importantly, we demonstrated that miR-129 increased the cytotoxic effect of 5- fluorouracil, in vitro and in vivo. We expect that our findings will provide a better insight into the role of microRNAs in cancer and will allow us to carry these molecules into clinical application.
Autorenporträt
I received my PhD from Stony Brook University in 2013. I published six manuscripts, including four first-author articles in graduate school, focusing on mechanisms of tumor cell survival and its influence on cancer natural history and prognosis. Currently, I work as a research fellow at the MGH Cancer Center and Harvard Medical School.