United States government. Defense Nuclear firms, Hoffman-LaRoche and Ciba-Geigy, and by Agency, Armed Forces Radiobiology Research In the American firm, Travenol. stitute. SIEGMUNDJ. BAUM Furthermore, we greatly appreciate the gener G. DAVID LEDNEY ous financial support by the Swiss pharmaceutical vi Xlll List of Contributors Part I Regulation of Stem Cell Proliferation L. G. Lajtha 1 Regulation of Stem Cell Proliferation 3 L. G. Lajtha and E. G. Wright Introduction 3 Experimental Evidence 3 Summary 7 References 7 Contents 2 Surface Antigens of Hemopoietic Stem Cells: The Expression of BAS,…mehr
United States government. Defense Nuclear firms, Hoffman-LaRoche and Ciba-Geigy, and by Agency, Armed Forces Radiobiology Research In the American firm, Travenol. stitute. SIEGMUNDJ. BAUM Furthermore, we greatly appreciate the gener G. DAVID LEDNEY ous financial support by the Swiss pharmaceutical vi Xlll List of Contributors Part I Regulation of Stem Cell Proliferation L. G. Lajtha 1 Regulation of Stem Cell Proliferation 3 L. G. Lajtha and E. G. Wright Introduction 3 Experimental Evidence 3 Summary 7 References 7 Contents 2 Surface Antigens of Hemopoietic Stem Cells: The Expression of BAS, Thy-1, and H-2 Antigens on CFU-s 9 Ger van den Engh, Jim Russell, and Diane de Cicco Introduction 9 Materials and Methods 10 Results 11 Discussion 13 Summary 14 Acknowledgments 14 References 15 3 The Regulation of Hemopoiesis: Effect of Thymosin or Thymocytes in a Diffusion Chamber 17 S. J. Sharkis, A. Ahmed, L. L. Sensenbrenner, W. W. Jedrzejczak, A. L. Goldstein, and K. W. Sell Introduction 17 Materials and Methods 17 Results 18 Discussion 20 Summary 21 Acknowledgments 21 References 21 4 Anti-CFU-s Activity of Rabbit Anti mouse Brain Serum: Mechanism of Action 23 Solomon S. Adler, Richard D. Kuznetsky, and Frank E. Trobaugh, Jr. Introduction 23 Materials and Methods 23 Results 26 Discussion 29 Summary 31 Acknowledgments 31 References 31 vii Contents Part II Ralph van Furth, Theo J. L. M. Goud, and Physiology of Committed Dick van Waarde Stem Cells 33 Introduction 65 D.
I Regulation of Stem Cell Proliferation.- 1 Regulation of Stem Cell Proliferation.- 2 Surface Antigens of Hemopoietic Stem Cells: The Expression of BAS, Thy-1, and H-2 Antigens on CFU-s.- 3 The Regulation of Hemopoiesis: Effect of Thymosin or Thymocytes in a Diffusion Chamber.- 4 Anti-CFU-s Activity of Rabbit Anti-mouse Brain Serum: Mechanism of Action.- II Physiology of Committed Stem Cells.- 5 The Control of Neutrophil and Macrophage Production at the Progenitor Cell Level.- 6 The Mononuclear Phagocyte and Its Regulatory Interactions in Hemopoiesis.- 7 Analysis of the Cells Forming Pure and Mixed Erythroid Colonies in Agar after Stimulation by Pokeweed Mitogen-stimulated, Spleen-conditioned Medium.- 8 Current Studies on the Proliferation of Cells of the Mononuclear Phagocyte System.- 9 Colony-forming Cells in the Thymus and Mesenteric Lymph Nodes of Mice Engrafted with Lewis Lung Carcinoma Cells.- III Transplantation Immunology.- 10 Expression of Normal and Leukemia associated Antigens on Blood Cell Malignancies.- 11 Leukocyte Transfusions for the Modification of Host-versus-graft Reactions in Dogs.- 12 Minor Histocompatibility Systems in Dogs.- 13 The Role of Mononuclear Phagocytes in the Defense against Infections and Malignancies.- 14 Enhancement of Immunological Responses by Methotrexate Pretreatment as a Result of an Eventual Elimination of Suppressor Cells.- 15 Syngeneic and Autologous Bone Marrow Transplantation after Noncurative Chemotherapy with AAFC, DMM, and Cyclophosphamide in Tumor-bearing Mice.- IV Therapeutic Approaches to Aplastic Anemia.- 16 On the Pathogenesis and Treatment of Aplastic Anemia.- 17 Engraftment of HLA Identical Marrow in Treatment of Severe Aplastic Anemia: Results of 110 Consecutive Transplants.- 18 The Role of Cyclophosphamide and Total-body Irradiation in Marrow Transplantation for Severe Aplastic Anemia.- 19 Histocompatibility Testing for Bone- George W. Santos and Saul J. Sharkis marrow Grafting.- 20 Recent Developments in Histocompatibility Testing in Bone Marrow Transplantation.- 21 Transplantation of Lymphoid Cells in Patients with Severe Combined Immunodeficiency (SCID).- V Treatment of Leukemia.- 22 Experience with Syngeneic Marrow Transplantation in Brown-Norway and Wistar-Furth Rat Models of Acute Myelogenous Leukemia.- 23 Marrow Transplantation for Acute Leukemia.- 24 Use of Decontamination and a Protected Environment to Prevent Secondary Disease following Adoptive Immunotherapy of Acute Leukemia in Mice.- 25 Procurement of Proliferative and Quiescent Acute Leukemia Cells by Centrifugal Elutriation.- VI Advances in Experimental Hematology.- 26 Cellular Requirements for Induction of Colony-stimulating Factor in Lymphoid Cell Cultures Stimulated by T- and B-Cell Mitogens.- 27 Serum Blocking Factor-mediated Decrease of T-Cell Immunity Induced by Soluble Histocompatibility Antigens (SHA); Similar Effects of Antibody-free SHA-raised and Hemagglutinating enhancing Sera.- 28 Ultrastructural Analysis of Preserved Dog Granulocytes.- 29 Relationship between Colony-forming Cells in Diffusion Chambers in Vivo (CFU-d) and Colony-forming Cells in Agar in Vitro (CFU-c): 22j Physical Separation and Kinetics in Culture.
I Regulation of Stem Cell Proliferation.- 1 Regulation of Stem Cell Proliferation.- 2 Surface Antigens of Hemopoietic Stem Cells: The Expression of BAS, Thy-1, and H-2 Antigens on CFU-s.- 3 The Regulation of Hemopoiesis: Effect of Thymosin or Thymocytes in a Diffusion Chamber.- 4 Anti-CFU-s Activity of Rabbit Anti-mouse Brain Serum: Mechanism of Action.- II Physiology of Committed Stem Cells.- 5 The Control of Neutrophil and Macrophage Production at the Progenitor Cell Level.- 6 The Mononuclear Phagocyte and Its Regulatory Interactions in Hemopoiesis.- 7 Analysis of the Cells Forming Pure and Mixed Erythroid Colonies in Agar after Stimulation by Pokeweed Mitogen-stimulated, Spleen-conditioned Medium.- 8 Current Studies on the Proliferation of Cells of the Mononuclear Phagocyte System.- 9 Colony-forming Cells in the Thymus and Mesenteric Lymph Nodes of Mice Engrafted with Lewis Lung Carcinoma Cells.- III Transplantation Immunology.- 10 Expression of Normal and Leukemia associated Antigens on Blood Cell Malignancies.- 11 Leukocyte Transfusions for the Modification of Host-versus-graft Reactions in Dogs.- 12 Minor Histocompatibility Systems in Dogs.- 13 The Role of Mononuclear Phagocytes in the Defense against Infections and Malignancies.- 14 Enhancement of Immunological Responses by Methotrexate Pretreatment as a Result of an Eventual Elimination of Suppressor Cells.- 15 Syngeneic and Autologous Bone Marrow Transplantation after Noncurative Chemotherapy with AAFC, DMM, and Cyclophosphamide in Tumor-bearing Mice.- IV Therapeutic Approaches to Aplastic Anemia.- 16 On the Pathogenesis and Treatment of Aplastic Anemia.- 17 Engraftment of HLA Identical Marrow in Treatment of Severe Aplastic Anemia: Results of 110 Consecutive Transplants.- 18 The Role of Cyclophosphamide and Total-body Irradiation in Marrow Transplantation for Severe Aplastic Anemia.- 19 Histocompatibility Testing for Bone- George W. Santos and Saul J. Sharkis marrow Grafting.- 20 Recent Developments in Histocompatibility Testing in Bone Marrow Transplantation.- 21 Transplantation of Lymphoid Cells in Patients with Severe Combined Immunodeficiency (SCID).- V Treatment of Leukemia.- 22 Experience with Syngeneic Marrow Transplantation in Brown-Norway and Wistar-Furth Rat Models of Acute Myelogenous Leukemia.- 23 Marrow Transplantation for Acute Leukemia.- 24 Use of Decontamination and a Protected Environment to Prevent Secondary Disease following Adoptive Immunotherapy of Acute Leukemia in Mice.- 25 Procurement of Proliferative and Quiescent Acute Leukemia Cells by Centrifugal Elutriation.- VI Advances in Experimental Hematology.- 26 Cellular Requirements for Induction of Colony-stimulating Factor in Lymphoid Cell Cultures Stimulated by T- and B-Cell Mitogens.- 27 Serum Blocking Factor-mediated Decrease of T-Cell Immunity Induced by Soluble Histocompatibility Antigens (SHA); Similar Effects of Antibody-free SHA-raised and Hemagglutinating enhancing Sera.- 28 Ultrastructural Analysis of Preserved Dog Granulocytes.- 29 Relationship between Colony-forming Cells in Diffusion Chambers in Vivo (CFU-d) and Colony-forming Cells in Agar in Vitro (CFU-c): 22j Physical Separation and Kinetics in Culture.
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