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ACTUALITY OF PROBLEM. Rheumatoid arthritis (RA) ¿ is the most common inflammatory joint disease which characterized by erosive symmetric polyarthritis in combination with systemic immunological visceral damaging. According to WHO the prevalence of RA among population is 0.5 up to 1%. It was found that about 70% of the erosive and destructive changes in the joints develop within first 3-6 months after the initial stage of disease, which determines course of the poor prognosis.