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It is concluded that patients suffering from essential hypertension exhibit that biological system is under the oxidative stress where MDA shows indirect correlation with anti-oxidants particularly with SOD (r=-0.573 ) and catalase (r=-0.633 ) representing that anti-oxidants are involved in reducing the stress of biological system during hypertension. Moreover, indirect correlation between MDA and Vitamin D (r=-0.663 ) reflecting that biological system is also facing the malfunctioning of immune system during essential hypertension.