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beta-thalassemia is endemic in all countries of the Arab world. It is the most common genetic disorder in Egypt where it is considered to be the most common chronic hemolytic and the most common genetic disorder in Egypt. It is a major health problem with an estimated carrier rate of 9-10%. This maniscript concerning beta- Thalassemia patients. Here, we will discuss all about epidemiological, genetics, clinical picture, laboratory investigation and the Eryptosis as new era in beta- Thalassemic Egyptian patients.