Equine Clinical Immunology

Herausgeber: Felippe, M Julia B

• Gebundenes Buch

Produktbeschreibung

Equine Clinical Immunology offers comprehensive information on equine immunological disorders. * Provides a complete, equine-specific reference on clinical immunology * Focuses on clinically relevant information for the diagnosis and treatment of horses with immune disorders * Illustrates the concepts discussed using drawings, photographs, and tables * Presents key concepts, clinical assessment information, and treatment approaches in text boxes for ease of use * Offers a practical, clinically oriented approach ideal for equine specialists

Produktdetails

• Verlag: John Wiley & Sons / Open Stax Textbooks
• Seitenzahl: 344
• Erscheinungstermin: 19. Januar 2016
• Englisch
• Abmessung: 279mm x 216mm x 23mm
• Gewicht: 1179g
• ISBN-13: 9781118558874
• ISBN-10: 1118558871
• Artikelnr.: 42955787

Autorenporträt

M. Julia B. Felippe, MedVet, MSc, PhD, DACVIM, is an Associate Professor of Large Animal Medicine and Veterinary Curriculum Director at Cornell University's College of Veterinary Medicine in Ithaca, New York, USA.

Inhaltsangabe

Contributors
ix Preface
xi 1 The Immune System
1 M. Julia B. Felippe 1.1 Definition
1 1.2 The organs of the immune system
1 1.3 The immune cells and soluble molecules
2 1.4 B and T cell activation in lymphoid tissues
6 1.5 When the immune response goes wrong
9 References
10 2 The Immune System of the Young Horse
11 Rebecca L. Tallmadge 2.1 Definition
11 2.2 Equine immune system development
11 2.3 Unique susceptibilities and disorders of young horses
16 2.4 Vaccinology teaches about neonatal immunity
18 References
18 3 The Immune System of the Older Horse
23 Amanda A. Adams and David W. Horohov 3.1 Definition
23 3.2 Clinical conditions associated with aging
23 3.3 Immunosenescence and vaccination
23 3.4 Nutrition in enhancing immunity in the old horse
26 3.5 Conclusion
27 References
27 4 Anaphylaxis
31 Rolfe M. Radcliffe 4.1 Definition
31 4.2 Signalment and clinical signs
31 4.3 Immunologic mechanisms and etiologic associations
32 4.4 Diagnostics
33 4.5 Treatment
34 4.6 Prevention
36 4.7 Prognosis and clinical outcomes
37 References
37 5 Allergy
39 Bettina Wagner 5.1 Definition
39 5.2 Culicoides hypersensitivity
39 5.3 Urticaria
43 5.4 Recurrent airway obstruction
44 References
44 6 Immune-Mediated Cytopenias
47 Thomas J. Divers 6.1 Definition
47 6.2 Immune-mediated hemolytic anemia
47 6.3 Immune-mediated thrombocytopenia
50 6.4 Immune-mediated neutropenia
53 References
54 7 Bullous Diseases of the Skin and Mucosa
55 Jeanine Peters-Kennedy and Rebecca E. Ruby 7.1 Definition
55 7.2 Immune-mediated bullous dermatoses
55 7.3 Pemphigus complex
57 7.4 Cutaneous adverse drug reactions
61 7.5 Erythema multiforme
62 7.6 Lupus erythematosus
64 References
65 8 Serum Sickness
69 Lais R.R. Costa 8.1 Definition
69 8.2 Signalment and clinical signs
69 8.3 Immunologic mechanisms and etiologic associations
69 8.4 Diagnostics
71 8.5 Treatment and prevention
71 References
72 9 Vasculitis
73 James S. W. Prutton and Nicola Pusterla 9.1 Definition
73 9.2 Signalment and clinical signs
73 9.3 Immunologic mechanisms and etiologic associations
73 9.4 Diagnostics
75 9.5 Treatment
75 9.6 Thrombophlebitis
75 9.7 Pastern and cannon leukocytoclastic vasculitis
76 9.8 Drug-induced vasculitis
76 9.9 Photo-activated vasculitis (photodynamic drugs)
77 9.10 Strongylus vulgaris
77 9.11 Equine granulocytic anaplasmosis
77 9.12 Equine viral arteritis
78 9.13 Equine herpesvirus-1
78 9.14 African horse sickness
78 References
79 10 Purpura Hemorrhagica
83 Laszlo M. Hunyadi and Nicola Pusterla 10.1 Definition
83 10.2 Signalment and clinical signs
83 10.3 Immunologic mechanisms and etiologic associations
83 10.4 Diagnostics
84 10.5 Treatment and prevention
85 References
86 11 Glomerulonephritis
87 M. Julia B. Felippe 11.1 Definition
87 11.2 Signalment and clinical signs
87 11.3 Immunologic mechanisms and etiologic associations
87 11.4 Diagnostics
88 11.5 Treatment and prognosis
88 References
88 12 Inflammatory and Immune-Mediated Muscle Disorders
91 Sian Durward-Akhurst and Stephanie J. Valberg 12.1 Definition
91 12.2 Infarctive purpura hemorrhagica
91 12.3 Rhabdomyolysis associated with Streptococcus equi
93 12.4 Immune-mediated myositis in Quarter Horse-related breeds
94 12.5 Systemic calcinosis
96 12.6 Uncharacterized immune-mediated and inflammatory myopathies
97 12.7 Sarcocystis myositis
97 References
98 13 Granulomatous Diseases
101 Lais R.R. Costa 13.1 Definition
101 13.2 Signalment and clinical signs
101 13.3 Immunologic mechanisms and etiologic associations
101 13.4 Diagnostics
104 13.5 Treatment and prevention
105 13.6 Types of cell-mediated hypersensitivity reactions
105 References
110 14 Chronic Inflammatory Bowel Disease
113 Gillian A. Perkins 14.1 Definition
113 14.2 Signalment and clinical signs
113 14.3 Immunologic mechanisms and etiologic associations
113 14.4 Diagnostics
115 14.5 Treatment and prognosis
116 References
117 15 Recurrent Uveitis
121 Brian C. Gilger 15.1 Definition
121 15.2 Signalment and clinical signs
121 15.3 Immunologic mechanisms and etiologic associations
121 15.4 Diagnostics
123 15.5 Treatment and prevention
124 15.6 Prognosis and clinical outcomes
124 References
125 16 Recurrent Airway Obstruction and Summer Pasture-Associated Obstructive Pulmonary Disease
127 Michela Bullone and Jean-Pierre Lavoie 16.1 Definition
127 16.2 Signalment and clinical signs
127 16.3 Immunologic mechanisms and etiologic associations
128 16.4 Diagnostics
134 16.5 Treatments and prevention
136 References
137 17 Inflammatory Airway Disease
145 Mathilde Leclère and Jean-Pierre Lavoie 17.1 Definition
145 17.2 Signalment and clinical signs
145 17.3 Immunologic mechanisms and etiologic associations
145 17.4 Types of bronchoalveolar lavage fluid inflammation and cytokine profile
147 17.5 Links between IAD and heaves
148 17.6 Links between IAD and EIPH
148 17.7 Diagnostics
148 17.8 Treatment and prevention
149 17.9 Prognosis and clinical outcomes
150 References
150 18 Inflammation
Endotoxemia and Systemic Inflammatory Response Syndrome
153 Erin L. McConachie and Kelsey A. Hart 18.1 Definition
153 18.2 Signalment and clinical signs
154 18.3 Immunologic mechanisms and etiologic associations
155 18.4 Multi-systemic response triggered by inflammatory mediators
157 18.5 Diagnostics
160 18.6 Treatment
162 18.7 Prognosis and clinical outcome
166 References
166 19 Leukemia
173 Tracy Stokol 19.1 Definition
173 19.2 Classification of leukemias
173 19.3 Specialized diagnostic techniques for leukemia
173 19.4 Chronic leukemia
175 19.5 Acute leukemia
177 References
179 20 Lymphoma
181 SallyAnne L. Ness 20.1 Definition
181 20.2 Signalment and clinical signs
181 20.3 Forms of equine lymphoma
182 20.4 Immunologic mechanisms and etiologic associations
183 20.5 Diagnostics
183 20.6 Classification of lymphomas
185 20.7 Prognosis and treatment
186 20.8 Monitoring
189 References
189 21 Immunodeficiencies
193 M. Julia B. Felippe 21.1 Definition
193 21.2 Classification of immunodeficiencies
194 References
202 22 Immunologic Testing
205 M. Julia B. Felippe 22.1 Definition
205 22.2 Types of immunologic testing
205 References
211 23 Non-steroidal Anti-inflammatories
213 Michelle H. Barton 23.1 Definition
213 23.2 Non-steroidal anti-inflammatory drugs
213 References
228 24 Immunosuppressive Therapy
237 M. Julia B. Felippe 24.1 Definition
237 24.2 Types of immunosuppressive drugs
237 References
240 25 Immunomodulators
243 Elizabeth G. Davis 25.1 Definition
243 25.2 Immunologic mechanisms
243 25.3 Commercially available immunostimulants for use in horses
244 References
249 26 Immunoglobulin Therapy
251 Elizabeth G. Davis 26.1 Definition
251 26.2 Immunologic mechanisms
251 References
254 27 Plasmapheresis
257 Nathan M. Slovis 27.1 Definition
257 27.2 Methods for preparing plasma products
257 27.3 Apheresis
258 27.4 Therapeutic plasmapheresis
258 27.5 Complications of therapeutic plasmapheresis
260 References
260 28 Principles of Vaccination
263 Noah D. Cohen and Angela I. Bordin 28.1 Definition
263 28.2 Efficacy and effectiveness of vaccines
263 28.3 Safety of vaccines
271 28.4 Key knowledge-gaps in equine vaccinology
273 28.5 Protocols for vaccination
275 References
276 29 Types of Vaccines
279 Angela I. Bordin and Noah D. Cohen 29.1 Definition
279 29.2 Immunologic mechanisms
279 29.3 Immune responses to vaccination
282 29.4 Routes of vaccination
284 29.5 Adjuvants and vaccine delivery systems
285 29.6 Important diseases with unavailable effective vaccines
285 References
286 30 Transplantation Immunology
289 Rebecca L. Tallmadge 30.1 Definition
289 30.2 Equine MHC genes: genomic organization and variation
289 30.3 Determining equine MHC haplotypes
290 30.4 Immunosuppression and engraftment
291 30.5 Graft rejection
292 30.6 Current transplantation applications
293 References
294 31 Mesenchymal Stem Cell Therapy
297 Gerlinde R. Van de Walle
Catharina De Schauwer and Lisa A. Fortier 31.1 Definition
297 31.2 Regenerative functions of mesenchymal stem cells
297 31.3 Immunologic mechanisms and associations
298 31.4 Sources of equine mesenchymal stem cells
299 31.5 Characterization of equine mesenchymal stem cells
300 31.6 Applications of equine mesenchymal stem cells in equine regenerative medicine
302 References
306 32 Hematopoietic Stem Cell Transplantation
311 M. Julia B. Felippe 32.1 Definition
311 32.2 Hematopoietic stem cell sources
311 32.3 Pre-transplantation conditioning
313 32.4 Post-transplantation immunosuppression
313 32.5 Hematopoietic stem cell transplantation in the horse
313 References
315 Index
317