S.Thanga Pandiyan, S.Milton Prabu

Epigallocatechin gallate protects fluoride induced neurotoxicity

• Broschiertes Buch

Produktbeschreibung

Fluoride (Fl) exposure engenders neurodegeneration in the brain. The Neuroprotective role of EGCG against Fl induced neurotoxicity in rat hippocampus has not yet been explored so far. In this present exploration we focused to witness whether EGCG (40mg/kg) prevents the Fl induced oxidative stress in the brain of rats with special emphasis on hippocampus. Fl (25mg/kg) intoxication for 4 weeks shows decreased neurotransmitters (AChE, NP, DA and 5-HT) in the brain. The oxidative stress markers (ROS, TBARS, NO and PC) were significantly increased with decreased enzymatic (SOD, CAT, GPx, GR, GST, and G6PD) and non-enzymatic antioxidants (GSH, TSH and Vit.C) in Fl intoxicated rat hippocampus. Moreover, Fl intoxicated rats showed an intrinsic and extrinsic pathway mediated apoptosis in the hippocampus of rats. Fl significantly increased the DNA damage as evidenced by increased DNA fragmentation. Furthermore, the toxic impact of Fl on hippocampus was also proved by the immunohistochemical, histological and ultra-structural studies. Pre-administration of EGCG significantly protected the rat brain and hippocampus against Fl ROS by its strong antioxidant and free radical scavenging ability.

Produktdetails

• Verlag: LAP Lambert Academic Publishing
• Seitenzahl: 64
• Erscheinungstermin: 17. Mai 2016
• Englisch
• Abmessung: 220mm x 150mm x 4mm
• Gewicht: 113g
• ISBN-13: 9783659875144
• ISBN-10: 3659875147
• Artikelnr.: 45172137

Autorenporträt

Dr.S.Thangapandiyan has completed Doctoral degree from Annamalai University. He published his research findings in peer reviewed national and international journals with high impact factors. His research mainly focused on (Pharmacology and Toxicology) heavy metals induced oxidative stress mediated organs dysfunctions in rats.