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Lithium¿History and Pharmacology.- Indications for Lithium Therapy.- Lithium and the Cell.- Effects of Lithium on Brain Metabolism.- Effect of Lithium on the Thyroid Gland.- Effect of Lithium on the Pituitary, Gonads, Adrenal, and Pineal.- Effect of Lithium on Mineral Metabolism.- Effect of Lithium on Carbohydrate Metabolism.- Effect of Lithium on the Kidney.- Other Effects of Lithium Mediated through Metabolic Pathways.- Conclusion.