This book records the proceedings of the 5th International Symposium on cancer topics organised in collaboration with the Association for International Cancer Research, a cancer charity based in the United Kingdom. The Symposium was held at the Klinikum Steglitz, Free University of West Berlin, Germany, between 1 and 3 October 1987. The Organising and Scientific Committees are deeply grateful to the President of the Free University, Professor Heckelmann, for allowing us to meet in the Klinikum Steglitz and for the University's generous financial support. It was a special pleasure to have a…mehr
This book records the proceedings of the 5th International Symposium on cancer topics organised in collaboration with the Association for International Cancer Research, a cancer charity based in the United Kingdom. The Symposium was held at the Klinikum Steglitz, Free University of West Berlin, Germany, between 1 and 3 October 1987. The Organising and Scientific Committees are deeply grateful to the President of the Free University, Professor Heckelmann, for allowing us to meet in the Klinikum Steglitz and for the University's generous financial support. It was a special pleasure to have a positive and generous input from the West Berlin Senate. Their support was crucial in making the Symposium a scientific success. The Symposium received financial support from a number of sponsors, and we are indeed happy to acknowledge our gratitude to them: Behringwerke AG, Bert hold AG, Boehringer Mannheim GmbH, the British Council, Deutsche Abbott GmbH, Deutsche Bank AG, Du Pont De Nemours GmbH, Knoll AG, Krewel werke GmbH, Nunc GmbH, Schering AG, Schwarz GmbH and Varian GmbH. The Symposium was the most ambitious so far mounted by the Association for International Cancer Research. The organisation and planning were carried through by an Organising Committee including Professor J. Hammerstein, Profes sor K. D. Asmus, Barbara Steiger and Renate Nigam. The Scientific Committee included Dr. D. C. H. McBrien, Professor T. Dormandy, Professor K. R. Rees, Pro fessor M. U. Dianzani and Professor H. Esterbauer. We thank these colleagues very much for their dedication, hard work and expert input.
Thromboxane A2 and Prostacyclin in Tumorigenesis.- Tumour Promoters and Prostaglandin Production.- Eicosanoid Regulation of Macrophage In Vitro Cytostatic function Towards Tumour Cells.- Role of Tumour Cell Eicosanoids and Membrane Glycoproteins IRGPIb and IRGPIIb/IIIa in Metastasis.- Alteration of Arachidonic Acid Metabolism in Rats after Inoculation of Tumour Cells and Their Subcellular Fractions: Role of Mononuclear Phagocytes as a Major Source of Enhanced Prostanoid Synthesis.- The Role of Platelet-Activating Factor and Structurally Related Alkyl Phospholipids in Immune and Cytotoxic Processes.- Platelet-Activating Factor in Renal Pathophysiology: The Effects of PAF Antagonists.- Interaction of Macrophages and Mast Cells in the Production of Prostaglandins and Leukotrienes.- Prostaglandin E2 and Thromboxane A2 Production by Human Peritoneal Macrophages: Effect of Mitomycin C, Nitrogen Mustard and Cyclosporin A.- Uterine Lipoxygenase Pathways.- Modulation of Ocular Eicosanoid Biosynthesis by Oxidants and Antioxidants.- Endogenous Formation of Leukotriene D4 During Systematic Anaphylaxis in the Guinea Pig.- Theoretical Calculations of the Structures of Some Prostaglandins and Inhibitors of Lipoxygenase.- Lipid Peroxidation and Cell Division in Normal and Tumour Tissues.- The Involvement of Free Radicals and Lipid Peroxidation in Carcinogenesis.- Diene Conjugation and Peroxidation in Precancer.- Oxygen Radical Regulation of Vascular Reactivity.- Arachidonic Acid-Induced Activation of NADPH Oxidase in Membranes of Human Neutrophils and HL-60 Leukemic Cells is Regulated by Guanine Nucleotide-Binding Proteins and is Independent of Ca2+ and Protein Kinase C.- Biochemistry of Oxidative Stress: Recent Experimental Work.- Lipid Peroxidation and Irreversible Hepatocyte Damage.- Lipid Peroxidation, Antioxidants and Regenerating Rat Liver.- Effect of Peroxidative Conditions on Human Plasma Low-Density Lipoproteins.- Studies on the Oxygen Dependance of Lipid Peroxidation.- Iron-Induced Lipid Peroxidation and Inhibition of Proliferation in Animal Tumour Cells.- Ethane and n-Pentane Formation in a Reconstituted Microsomal Lipid Peroxidation System.- The CCl4-Induced Increase of Free Arachidonate in Hepatocytes.- Lipid Peroxidation Products and Carcinogenesis: Preliminary Evidence of n-Alkanal Genotoxicity.- Detection of 4-Hydroxynonenal and Other Lipid Peroxidation Products in the Liver of Allyl Alcohol-Intoxicated Mice.- Liver Cell Heterogeneity in Biotransformation of Carcinogenic Polycyclic Hydrocarbons.- Free Radical Intermediates of Carcinogenic Hydrazines.- Studies on Cancer of the Human Cervix in Relation to Thiol-Groups.- Microphotometric Determination of Protein Thiols and Disulphides in Tissue Samples from the Human Uterine Cervix and the Skin Reveal a "Field Effect" in the Surroundings of Benign and Malignant Tumours.- Protein-Thiol Levels in Relation to Deviation from Normality in Rat Liver Cell Lines.- Computerized Digital Video Microdensitometry Applied to the Quantitation of Intracellular Macromolecules or Their Functional Groups.- Modulation of Hepatocarcinogenicity of Aflatoxin B1 by the Chlorinated Insecticide DDT.- Intratumoral Fibrin Stabilization.
Thromboxane A2 and Prostacyclin in Tumorigenesis.- Tumour Promoters and Prostaglandin Production.- Eicosanoid Regulation of Macrophage In Vitro Cytostatic function Towards Tumour Cells.- Role of Tumour Cell Eicosanoids and Membrane Glycoproteins IRGPIb and IRGPIIb/IIIa in Metastasis.- Alteration of Arachidonic Acid Metabolism in Rats after Inoculation of Tumour Cells and Their Subcellular Fractions: Role of Mononuclear Phagocytes as a Major Source of Enhanced Prostanoid Synthesis.- The Role of Platelet-Activating Factor and Structurally Related Alkyl Phospholipids in Immune and Cytotoxic Processes.- Platelet-Activating Factor in Renal Pathophysiology: The Effects of PAF Antagonists.- Interaction of Macrophages and Mast Cells in the Production of Prostaglandins and Leukotrienes.- Prostaglandin E2 and Thromboxane A2 Production by Human Peritoneal Macrophages: Effect of Mitomycin C, Nitrogen Mustard and Cyclosporin A.- Uterine Lipoxygenase Pathways.- Modulation of Ocular Eicosanoid Biosynthesis by Oxidants and Antioxidants.- Endogenous Formation of Leukotriene D4 During Systematic Anaphylaxis in the Guinea Pig.- Theoretical Calculations of the Structures of Some Prostaglandins and Inhibitors of Lipoxygenase.- Lipid Peroxidation and Cell Division in Normal and Tumour Tissues.- The Involvement of Free Radicals and Lipid Peroxidation in Carcinogenesis.- Diene Conjugation and Peroxidation in Precancer.- Oxygen Radical Regulation of Vascular Reactivity.- Arachidonic Acid-Induced Activation of NADPH Oxidase in Membranes of Human Neutrophils and HL-60 Leukemic Cells is Regulated by Guanine Nucleotide-Binding Proteins and is Independent of Ca2+ and Protein Kinase C.- Biochemistry of Oxidative Stress: Recent Experimental Work.- Lipid Peroxidation and Irreversible Hepatocyte Damage.- Lipid Peroxidation, Antioxidants and Regenerating Rat Liver.- Effect of Peroxidative Conditions on Human Plasma Low-Density Lipoproteins.- Studies on the Oxygen Dependance of Lipid Peroxidation.- Iron-Induced Lipid Peroxidation and Inhibition of Proliferation in Animal Tumour Cells.- Ethane and n-Pentane Formation in a Reconstituted Microsomal Lipid Peroxidation System.- The CCl4-Induced Increase of Free Arachidonate in Hepatocytes.- Lipid Peroxidation Products and Carcinogenesis: Preliminary Evidence of n-Alkanal Genotoxicity.- Detection of 4-Hydroxynonenal and Other Lipid Peroxidation Products in the Liver of Allyl Alcohol-Intoxicated Mice.- Liver Cell Heterogeneity in Biotransformation of Carcinogenic Polycyclic Hydrocarbons.- Free Radical Intermediates of Carcinogenic Hydrazines.- Studies on Cancer of the Human Cervix in Relation to Thiol-Groups.- Microphotometric Determination of Protein Thiols and Disulphides in Tissue Samples from the Human Uterine Cervix and the Skin Reveal a "Field Effect" in the Surroundings of Benign and Malignant Tumours.- Protein-Thiol Levels in Relation to Deviation from Normality in Rat Liver Cell Lines.- Computerized Digital Video Microdensitometry Applied to the Quantitation of Intracellular Macromolecules or Their Functional Groups.- Modulation of Hepatocarcinogenicity of Aflatoxin B1 by the Chlorinated Insecticide DDT.- Intratumoral Fibrin Stabilization.
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