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With the development of new effective and potent therapies for chronic liver diseases especially for viral hepatitis C and B; the need for liver biopsy in diagnosing the stage of hepatic fibrosis is decreasing and the role of noninvasive methods for assessment of hepatic fibrosis is becoming increasingly popular. This book represents a project that aimed at development of a new score of serum biomarkers for noninvasive assessment of hepatic fibrosis and cirrhosis. This book also highlights the relation between elevation of different tumor markers and the presence of liver fibrosis and cirrhosis. I hope this book will be beneficial to physicians and researchers interested in liver diseases and hepatology research.