Effect of antidiabetic agents on hepatic functions in diabetic animals
Shivkumar Rathod
Broschiertes Buch

Effect of antidiabetic agents on hepatic functions in diabetic animals

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Type 2 diabetes is a progressive disorder with a consistent and steady increase in HbA1c over time associated with enhanced risk of micro- and macrovascular complications and a substantial reduction in life expectancy. Administration of Streptozotocin (65 mg/kg, i.p) and Nicotinamide (110 mg/kg, i.p) produced symptoms such as hyperglycemia, loss of body weight. Also impaired glucose metabolism and altered hepatic function. The treatment with Metformin (50 mg/kg, p.o) reduced elevated levels of serum AST, ALT, ALP, GammaGTP and CPK levels which show the protective effect of Metformin (50 mg/kg/...