Developmental Neurotoxicology Research
Principles, Models, Techniques, Strategies, and Mechanisms
Herausgeber: Wang, Cheng; Slikker, William
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How preclinical research approaches can inform clinical interventions?and vice versa Because of the complexity and temporal features of the developing brain, the developing nervous system may be more susceptible to neurotoxic insults. The study of neurodevelopmental toxicology has great potential for helping to advance the understanding of brain-related biological processes, including neuronal plasticity, neurodegeneration/regeneration, toxicity, and effectiveness of many products. Developmental Neurotoxicology Research delineates how systems biology, pharmacogenomic, and behavioral approaches...
How preclinical research approaches can inform clinical interventions?and vice versa Because of the complexity and temporal features of the developing brain, the developing nervous system may be more susceptible to neurotoxic insults. The study of neurodevelopmental toxicology has great potential for helping to advance the understanding of brain-related biological processes, including neuronal plasticity, neurodegeneration/regeneration, toxicity, and effectiveness of many products. Developmental Neurotoxicology Research delineates how systems biology, pharmacogenomic, and behavioral approaches, as applied to neurodevelopmental toxicology, provide a structure to arrange information in a biological model. The book presents: * Cross-cutting research tools and animal models along with applications to the studies associated with potential anesthetic-induced developmental neurotoxicity * The developmental basis of adolescent or adult onset of disease * Risk assessment of methyl mercury and its effects on neurodevelopment * Challenges in the field to identify environmental factors of relevance to autism * The strategy and progress of epilepsy research Incorporating new, post-genomic techniques, this book provides researchers with effective tools for dissecting the mechanisms underlying pharmacological and toxicological phenomena associated with the exposure to drugs or environmental toxicants during development.
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