Gandi Anusha

DEVELOPMENT AND VALIDATION OF MISOPROSTOL BY USING UV-SPECTROPHOTOMETR

• Broschiertes Buch

Produktbeschreibung

The present study aimed to develop and validate a stability-indicating UV spectroscopic method for the quantification of misoprostol in bulk form, which is commonly used for treating NSAID-related ulcers. The study used only the bulk form of misoprostol and selected 0.1N HCl as the solvent after conducting pre-solubility tests. The method was developed and validated using the ELICO-Double beam SL-120/UV spectrophotometer. Based on the physical parameters and solubility of misoprostol, a standard stock solution of the drug was prepared, and the absorbance maxima were determined to occur at 281nm. Linearity was established by preparing solutions ranging from 2-10 µg/ml, and the study followed the Q3D guidelines outlined by the ICH.The developed UV spectroscopic method for misoprostol quantification in bulk form proved to be rapid, simple, cost-effective, and suitable for its specific determination. The method adhered to established guidelines and exhibited good linearity, with satisfactory LOD, LOQ, accuracy, and precision.

Produktdetails

• Verlag: LAP Lambert Academic Publishing
• Seitenzahl: 52
• Erscheinungstermin: 4. Juli 2023
• Englisch
• Abmessung: 220mm x 150mm x 4mm
• Gewicht: 96g
• ISBN-13: 9786206184140
• ISBN-10: 6206184145
• Artikelnr.: 68498522

Autorenporträt

Gandi Anusha est actuellement professeur adjoint au Vignan Institute of Pharmaceutical Technology, Duvvada, Visakhapatnam, A.P, Inde. Elle a obtenu un diplôme de maîtrise en pharmacie avec une spécialisation en analyse pharmaceutique et assurance qualité à l'université technologique Jawaharlal Nehru, Kakinada, et poursuit un doctorat à l'université d'Andhra.