Alexander Lotz

Designing an antimicrobial and cell-adhesive multilayer

How to counteract nosocomial infections associated with medical devices in hospitals

• Broschiertes Buch

Produktbeschreibung

In this work surface modifications were developed that bear cell-adhesive as well as antimicrobial properties. Fast cell adhesion and wound healing is desired for biomaterials since otherwise the material would be recognized as a foreign body and infectious bacteria could enter the cavity between material and tissue. Plasma polymerization was used as the deposition technique since a broad range of materials can be coated independent of their composition. As a cell-adhesive coating plasma polymerized allylamine was chosen since it is cell-friendly and offers a platform for wet chemical modifications such as grafting of fibronectin. Furthermore, it serves as a barrier layer for zinc and silver containing sub-layers that exhibit antimicrobial properties due to the release of zinc and silver. The layer systems were spectroscopically and microscopically investigated. Cell-adhesive and antimicrobial properties were tested with various types of cells and bacteria.

Produktdetails

• Verlag: Südwestdeutscher Verlag für Hochschulschriften
• Aufl.
• Seitenzahl: 132
• Erscheinungstermin: 8. Juli 2015
• Englisch
• Abmessung: 220mm x 150mm x 9mm
• Gewicht: 192g
• ISBN-13: 9783838133430
• ISBN-10: 3838133439
• Artikelnr.: 35912478

Autorenporträt

studied Chemistry in Germany at the Technical University of Kaiserslautern and the Johannes-Gutenberg University of Mainz. He pursued his PhD studies on biomaterials and plasma polymerization at the Max Planck Institut for Polymer Research and was working with international partners on EU-projects to publish and patent his research.