Design, Synthesis & Anticancer screening of Novel 2-Phenazinamines

Design, Synthesis & Anticancer screening of Novel 2-Phenazinamines

Design, Synthesis and Anticancer screening of some New 2-Phenazinamines as Bcr-Abl Tyrosine kinase Inhibitors

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The present work is concerned with designing new phenazinamine derivatives using computer aided drug design and to perform insilico screening of designed phenazinamine derivatives. These compounds were designed on the basis of literature information, essential for anticancer activity through PASS, toxicity risk assessment, GQSAR and molecular docking studies. Compounds which were optimized and shortlisted by molecular modeling studies viz., new phenazinamine derivatives; were synthesized, structurally elucidated by spectroscopic studies and screened for invitro anticancer activity. It was foun...