Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology, Part C

Herausgegeben:Uversky, Vladimir N

• Gebundenes Buch

Produktbeschreibung

Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology, Part C, Volume 183 represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this volume include discussions on the evolution of disorder, consideration of the peculiarities of phase separation of the prion protein, a general discussion of the relationships between intrinsic disorder and protein functions, coverage of the structural and functional characterization of several important intrinsically disordered proteins, such as transcription factors, outer membrane porins, trans-membrane and membrane associated proteins with ID regions, discussion of molecular simulations of IDPs, and much more.

Produktdetails

• Progress in Molecular Biology and Translational Science Volume 183
• Verlag: Academic Press / Elsevier Science & Technology
• Artikelnr. des Verlages: S1877-1173(21)X0008-7
• Englisch
• Abmessung: 23mm x 152mm x 229mm
• Gewicht: 802g
• ISBN-13: 9780323852999
• Artikelnr.: 67578926

Autorenporträt

Vladimir N. Uversky is a Professor at the Department of Molecular Medicine, University of
South Florida, USA. He obtained B.S. and M.S. degrees in Physics from Leningrad State
University in Russia in 1986, then completed Ph.D. and Doctor of Sciences (D.Sc.) degrees
in Physics and Mathematics (field of study - Biophysics) at the Moscow Institute of Physics and Technology (1991) and the Institute Experimental and Theoretical Biophysics of the Russian Academy of Sciences (1998), respectively. In 1998, he moved to the University of California Santa Cruz to study protein folding, misfolding, protein conformation diseases, and protein intrinsic disorder phenomena. In 2004, he was invited to join the Indiana University School of Medicine to primary work on intrinsically disordered proteins, and since 2010 has been on faculty at the University of South Florida. He has authored over 850 scientific publications and edited several books and book series on protein structure.

Inhaltsangabe

1. Intrinsic disorder and phase transitions: Pieces in the puzzling role of the prion protein in health and disease



Mariana J. do Amaral and Yraima Cordeiro



2. Functions of intrinsically disordered proteins through evolutionary lenses



Mátyás Pajkos and Zsuzsanna Dosztányi



3. Non-specific porins of Gram-negative bacteria as proteins containing intrinsically disordered regions with amyloidogenic potential



Olga D. Novikova, Vladimir N. Uversky and Elena A. Zelepuga



4. Intrinsic disorder in integral membrane proteins



Brian J. Aneskievich, Rambon Shamilov and Olga Vinogradova



5. Molecular simulations of IDPs: From ensemble generation to IDP interactions leading to disorder-to-order transitions



Hebah Fatafta, Suman Samantray, Abdallah Sayyed-Ahmad, Orkid Coskuner-Weber and Birgit Strodel



6. Target-binding behavior of IDPs via pre-structured motifs



Do-Hyoung Kim and Kyou-Hoon Han



7. The role of dancing duplexes in biology and disease



Heather M. Forsythe and Elisar Barbar



8. Intrinsic disorder in protein kinase A anchoring proteins signaling complexes



Mateusz Dyla and Magnus Kjaergaard



9. Protein intrinsic disorder on a dynamic nucleosomal landscape



Sveinn Bjarnason, Sarah F. Ruidiaz, Jordan McIvor, Davide Mercadante and Pétur O. Heidarsson



10. Flexible spandrels of the global plant virome: Proteomic-wide evolutionary patterns of structural intrinsic protein disorder elucidate modulation at the functional virus-host interplay



Rachid Tahzima, Annelies Haegeman, Sébastien Massart and Eugénie Hébrard